Outcomes of prenatally diagnosed lung lesions in multigestational pregnancies

Jesse D. Vrecenak, Lori J. Howell, Nahla Khalek, Julie S. Moldenhauer, Mark Paul Johnson, Beverly G. Coleman, Teresa Victoria, Holly L. Hedrick, William H. Peranteau, Alan W. Flake, N. Scott Adzick

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Background: The outcomes of prenatally diagnosed lung lesions in the context of multigestational pregnancies are unknown.

Methods: Of 960 fetal lung lesion cases evaluated at a single tertiary center over 16 years, 30 occurred in multigestational pregnancies. We reviewed this series to aid in prenatal counseling of affected families and to provide prognostic information for decision making. Pre- and postnatal clinical characteristics were gathered for these pregnancies, and the morbidity and mortality were determined for both affected and normal fetuses, whether twins or triplets.

Results: Mortality was found to be 3/30 (10%) for affected fetuses, and morbidity in normal co-twins was consistent with the degree of prematurity. No morbidity was seen in cotwins born at or after 36 weeks of gestation. Median gestational age at delivery was 35 5/7 weeks.

Conclusions: Outcomes for the affected fetus correlate with the size and pathophysiologic consequences of the lesion and are not worse than previously reported outcomes for similar lesions in singleton pregnancies, while morbidity in the normal cotwin is consistent with prematurity related to the fetal age of the multiple gestation at delivery, irrespective of the fetal lung lesion.

Original languageEnglish
Pages (from-to)312-319
Number of pages8
JournalFetal Diagnosis and Therapy
Issue number4
StatePublished - Dec 17 2014


  • Bronchial atresia
  • Bronchogenic cyst
  • Bronchopulmonary sequestration
  • Congenital cystic adenomatoid malformation
  • Fetal therapy
  • Hybrid lung lesion
  • Lymphangioma
  • Multiple gestation


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