TY - JOUR
T1 - Outcomes of congenital diaphragmatic hernia in the modern era of management
AU - Wynn, Julia
AU - Krishnan, Usha
AU - Aspelund, Gudrun
AU - Zhang, Yuan
AU - Duong, Jimmy
AU - Stolar, Charles J.H.
AU - Hahn, Eunice
AU - Pietsch, John
AU - Chung, Dai
AU - Moore, Donald
AU - Austin, Eric
AU - Mychaliska, George
AU - Gajarski, Robert
AU - Foong, Yen Lim
AU - Michelfelder, Erik
AU - Potolka, Douglas
AU - Bucher, Brian
AU - Warner, Brad
AU - Grady, Mark
AU - Azarow, Ken
AU - Fletcher, Scott E.
AU - Kutty, Shelby
AU - Delaney, Jeff
AU - Crombleholme, Timothy
AU - Rosenzweig, Erika
AU - Chung, Wendy
AU - Arkovitz, Marc S.
N1 - Funding Information:
Supported by the National Institute of Health ( National Institute of Child Health and Development R-01 HD057036 - Identification of Novel Genes for Congenital Diaphragmatic Hernia) and Columbia University's Clinical and Translational Science Award ( UL1 RR024156 from National Center for Advancing Translational Sciences-National Center for Research Resources /National Institutes of Health). The authors declare no conflicts of interest.
PY - 2013
Y1 - 2013
N2 - Objective: To identify clinical factors associated with pulmonary hypertension (PH) and mortality in patients with congenital diaphragmatic hernia (CDH). Study design: A prospective cohort of neonates with a diaphragm defect identified at 1 of 7 collaborating medical centers was studied. Echocardiograms were performed at 1 month and 3 months of age and analyzed at a central core by 2 cardiologists independently. Degree of PH and survival were tested for association with clinical variables using Fischer exact test, χ2, and regression analysis. Results: Two hundred twenty patients met inclusion criteria. Worse PH measured at 1 month of life was associated with higher mortality. Other factors associated with mortality were need for extracorporeal membrane oxygenation, patients inborn at the treating center, and patients with a prenatal diagnosis of CDH. Interestingly, patients with right sided CDH did not have worse outcomes. Conclusions: Severity of PH is associated with mortality in CDH. Other factors associated with mortality were birth weight, gestational age at birth, inborn status, and need for extracorporeal membrane oxygenation.
AB - Objective: To identify clinical factors associated with pulmonary hypertension (PH) and mortality in patients with congenital diaphragmatic hernia (CDH). Study design: A prospective cohort of neonates with a diaphragm defect identified at 1 of 7 collaborating medical centers was studied. Echocardiograms were performed at 1 month and 3 months of age and analyzed at a central core by 2 cardiologists independently. Degree of PH and survival were tested for association with clinical variables using Fischer exact test, χ2, and regression analysis. Results: Two hundred twenty patients met inclusion criteria. Worse PH measured at 1 month of life was associated with higher mortality. Other factors associated with mortality were need for extracorporeal membrane oxygenation, patients inborn at the treating center, and patients with a prenatal diagnosis of CDH. Interestingly, patients with right sided CDH did not have worse outcomes. Conclusions: Severity of PH is associated with mortality in CDH. Other factors associated with mortality were birth weight, gestational age at birth, inborn status, and need for extracorporeal membrane oxygenation.
UR - http://www.scopus.com/inward/record.url?scp=84879420837&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2012.12.036
DO - 10.1016/j.jpeds.2012.12.036
M3 - Article
C2 - 23375362
AN - SCOPUS:84879420837
SN - 0022-3476
VL - 163
SP - 114-119.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -