TY - JOUR
T1 - Outcomes from the International Society of Nephrology Hemolytic Uremic Syndromes International Forum
AU - Forum Participants
AU - Kavanagh, David
AU - Ardissino, Gianluigi
AU - Brocklebank, Vicky
AU - Bouwmeester, Romy N.
AU - Bagga, Arvind
AU - ter Heine, Rob
AU - Johnson, Sally
AU - Licht, Christoph
AU - Ma, Alison L.T.
AU - Noris, Marina
AU - Praga, Manuel
AU - Rondeau, Eric
AU - Sinha, Aditi
AU - Smith, Richard J.H.
AU - Sheerin, Neil S.
AU - Trimarchi, H.
AU - Wetzels, Jack F.M.
AU - Vivarelli, Marina
AU - Van de Kar, Nicole C.A.J.
AU - Greenbaum, Larry A.
AU - Lungu, Adrian Catalin
AU - Żurowska, Aleksandra
AU - Gerogianni, Alexandra
AU - Durkan, Anne
AU - Schijvens, Anne
AU - Lapeyraque, Anne Laure
AU - Java, Anuja
AU - Awan, Atif
AU - Covella, Bianca
AU - Dixon, Brad
AU - El Sissy, Carine
AU - Duinevel, Caroline
AU - Maville, Christine
AU - Turudic, Daniel
AU - Karpman, Diana
AU - Haffner, Dieter
AU - Trembecka-Dubel, Elżbieta
AU - Ozaltin, Fatih
AU - Emma, Francesco
AU - Schaefer, Franz
AU - Kang, Hee Gyung
AU - Trimarchi, Hernán
AU - Trujillo, Hernando
AU - Ulasi, Ifeoma
AU - Ekwueme, Alex
AU - Menne, Jan
AU - Laurence, Jeffrey
AU - Calado, Joaquim
AU - Hofer, Johannes
AU - Zuber, Julien
AU - Oh, Jun
AU - Bakar, Karmila Abu
AU - Jackson, Kate Smith
AU - Milosevic, Danko
AU - Ariceta, Gema
AU - Claes, Kathleen J.
AU - Kaartinen, Kati
AU - Alhasan, Khalid
AU - Wijnsma, Kioa
AU - van den Heuvel, L. P.
AU - Alconcher, Laura
AU - Izabel de Holanda, Maria
AU - Szczepańska, Maria
AU - Meuleman, Marie Sophie
AU - Lemaire, Mathieu
AU - Harris, Meredith
AU - Michalopulos, Michael G.
AU - Malina, Michal
AU - Józsi, Mihály
AU - Stajić, Nataša
AU - Isbel, Nicole
AU - Walsh, Patrick
AU - Coccia, Paula A.
AU - Ramachandran, Raja
AU - Topaloglu, Rezan
AU - Timmermans, Sjoerd A.M.E.G.
AU - Chauvet, Sophie
AU - Levart, Tanja Kersnik
AU - Seeman, Tomas
AU - Tasic, Velibor
AU - Tesař, Vladimír
AU - Song, Wen Chao
AU - Zhang, Yuzhou
AU - Prohászka, Zoltán
N1 - Publisher Copyright:
© 2024 International Society of Nephrology
PY - 2024/12
Y1 - 2024/12
N2 - Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.
AB - Hemolytic uremic syndromes (HUSs) are a heterogeneous group of conditions, only some of which are mediated by complement (complement-mediated HUS). We report the outcome of the 2023 International Society of Nephrology HUS International Forum where a global panel of experts considered the current state of the art, identified areas of uncertainty, and proposed optimal solutions. Areas of uncertainty and areas for future research included the nomenclature of HUS, novel complement testing strategies, identification of biomarkers, genetic predisposition to atypical HUS, optimal dosing and withdrawal strategies for C5 inhibitors, treatment of kidney transplant recipients, disparity of access to treatment, and the next generation of complement inhibitors in complement-mediated HUS. The current rationale for optimal patient management is described.
KW - C5
KW - acute kidney injury
KW - complement
KW - hemolytic uremic syndrome
KW - thrombotic microangiopathy
UR - http://www.scopus.com/inward/record.url?scp=85209153266&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2024.09.012
DO - 10.1016/j.kint.2024.09.012
M3 - Article
C2 - 39395628
AN - SCOPUS:85209153266
SN - 0085-2538
VL - 106
SP - 1038
EP - 1050
JO - Kidney International
JF - Kidney International
IS - 6
ER -