Outcome of surgically resected thymic carcinoma: A multicenter experience

Pier Luigi Filosso, Francesco Guerrera, Angelo Erino Rendina, Giulia Bora, Enrico Ruffini, Domenico Novero, Luigi Ruco, Domenico Vitolo, Marco Anile, Mohsen Ibrahim, Caterina Casadio, Ottavio Rena, Alberto Terzi, Paraskevas Lyberis, Alberto Oliaro, Federico Venuta

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Objective: Thymic carcinoma (TC) is a rare and invasive mediastinal tumor, with poor prognosis. Most of the previous published papers are single-institution based, reporting small series of patient, sometimes including palliative resection. This study collected patients with TC treated in 5 high-volume Italian Thoracic Surgery Institutions. Methods: A multicenter retrospective study of patients operated for TC between 2000 and 2011 was conducted. Exclusion criteria were: Neuroendocrine thymic neoplasms, debulking/palliative resection and tumor biopsy. Cause specific survival (CSS) was the primary endpoint. Results: Four hundred and seventy-eight patients underwent surgery for thymic malignancies: 40 of them (8.4%) had TC. Eleven (27.5%) received induction chemotherapy because of their radiological invasiveness. A complete resection (R0) was achieved in 36 (90%; 9/11 submitted to induction chemotherapy). Adjuvant radio/chemotherapy was offered to 37 patients, according to the type of surgical resection and tumor invasiveness. Three, 5 and 10-year survival rates were 79%, 75% and 58%. Recurrences developed in 10 patients. R0 resection (p<0.0003) and absence of tumor recurrences (p=0.03) resulted significant prognostic factors at univariate analysis. Independent CSS predictor was the achievement of a complete resection (p<0.05). Conclusions: TC is a rare and invasive mediastinal tumor. A multimodal approach is indicated especially in TC invasive forms. The achievement of a complete surgical resection is fundamental to improve survival.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalLung Cancer
Issue number2
StatePublished - Feb 1 2014
Externally publishedYes


  • Masaoka staging system
  • Myasthenia Gravis
  • Outcome
  • Surgery
  • Thymic carcinoma
  • Thymus

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    Filosso, P. L., Guerrera, F., Rendina, A. E., Bora, G., Ruffini, E., Novero, D., Ruco, L., Vitolo, D., Anile, M., Ibrahim, M., Casadio, C., Rena, O., Terzi, A., Lyberis, P., Oliaro, A., & Venuta, F. (2014). Outcome of surgically resected thymic carcinoma: A multicenter experience. Lung Cancer, 83(2), 205-210. https://doi.org/10.1016/j.lungcan.2013.11.015