Otosclerotic lesions in the inbred LP/J mouse

Richard A. Chole; Kenneth R. Henry

doi:10.1126/science.6879187

Otosclerotic lesions in the inbred LP/J mouse

Richard A. Chole
, Kenneth R. Henry

Department of Otolaryngology

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.

Original language	English
Pages (from-to)	881-882
Number of pages	2
Journal	Science
Volume	221
Issue number	4613
DOIs	https://doi.org/10.1126/science.6879187
State	Published - 1983

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title = "Otosclerotic lesions in the inbred LP/J mouse",

abstract = "Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.",

author = "Chole, \{Richard A.\} and Henry, \{Kenneth R.\}",

year = "1983",

doi = "10.1126/science.6879187",

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pages = "881--882",

journal = "Science",

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TY - JOUR

T1 - Otosclerotic lesions in the inbred LP/J mouse

AU - Chole, Richard A.

AU - Henry, Kenneth R.

PY - 1983

Y1 - 1983

N2 - Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.

AB - Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.

UR - https://www.scopus.com/pages/publications/0020592014

U2 - 10.1126/science.6879187

DO - 10.1126/science.6879187

M3 - Article

C2 - 6879187

AN - SCOPUS:0020592014

SN - 0036-8075

VL - 221

SP - 881

EP - 882

JO - Science

JF - Science

IS - 4613

ER -

Otosclerotic lesions in the inbred LP/J mouse

Abstract

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