Otosclerotic lesions in the inbred LP/J mouse

Richard A. Chole, Kenneth R. Henry

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.

Original languageEnglish
Pages (from-to)881-882
Number of pages2
JournalScience
Volume221
Issue number4613
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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