Abstract
Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.
| Original language | English |
|---|---|
| Pages (from-to) | 881-882 |
| Number of pages | 2 |
| Journal | Science |
| Volume | 221 |
| Issue number | 4613 |
| DOIs | |
| State | Published - Jan 1 1983 |
| Externally published | Yes |
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Cite this
Chole, R. A., & Henry, K. R. (1983). Otosclerotic lesions in the inbred LP/J mouse. Science, 221(4613), 881-882. https://doi.org/10.1126/science.6879187