Abstract
Inbred LP/J mice develop abnormal bony lesions that are grossly and histologically similar to the lesions of human otosclerosis. This is the first known occurrence of spontaneous otosclerosis-like lesions in an animal. As in the human disease, these lesions impair audition by immobilizing the ossicles of the middle ear. The LP/J mouse may be an animal model for this common human disease.
Original language | English |
---|---|
Pages (from-to) | 881-882 |
Number of pages | 2 |
Journal | Science |
Volume | 221 |
Issue number | 4613 |
DOIs | |
State | Published - 1983 |