Osteosclerosis, osteomalacia, and bone marrow aplasia: A combined late complication of thorotrast administration

William A. Murphy, Paul A. Seligman, Thomas Tillack, John O. Eichling, Steven L. Teitelbaum, J. Heinrich Joist

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

A 37-year-old female with thrombocytopenia since childhood developed diffuse osteosclerosis followed by bone marrow aplasia 23 years after Thorotrast administration. Tissue deposition of Thorotrast was documented by radiospectroscopy (liver, bone) and autoradiography (bone). Bone marrow failure in this patient was clinically ascribed to diffuse myelofibrosis, but at autopsy marrow fibrosis was only focal. An unsuspected bone mineralization defect was manifested by thick osteoid seams. It is suggested that osteosclerosis, osteomalacia, and bone marrow aplasia represent a combined experession of Thorotrast cytotoxicity.

Original languageEnglish
Pages (from-to)234-238
Number of pages5
JournalSkeletal Radiology
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1979

Keywords

  • Aplasia, bone marrow
  • Osteomalacia
  • Osteosclerosis
  • Radiation, effect of
  • Thorotrast

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