TY - JOUR
T1 - Osteopontin Promoter Polymorphism Is Associated With Increased Carotid Intima-Media Thickness
AU - de las Fuentes, Lisa
AU - Gu, C. Charles
AU - Mathews, Santhosh J.
AU - Reagan, Joann L.
AU - Ruthmann, Nicholas P.
AU - Waggoner, Alan D.
AU - Lai, Chung Fang
AU - Towler, Dwight A.
AU - Dávila-Román, Víctor G.
N1 - Funding Information:
This study was supported in part by National Institutes of Health grants K12RR023249 and KL2RR024994 (L.d.l.F), HL54473 (C.C.G.), R01HL69229 (D.A.T.), R01HL81138, R01HL71782, R01HL58878, K24HL67002, and P50Hl83762 (V.G.D.-R.), and M01RR00036 (General Clinical Research Center) (Washington University); Robert Wood Johnson Foundation grant 048875 (L.d.l.F); and a grant from the Barnes-Jewish Hospital Foundation to the Cardiovascular Imaging and Clinical Research Core Laboratory at the Washington University School of Medicine.
PY - 2008/8
Y1 - 2008/8
N2 - Background: Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation. Methods: An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70). Results: The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group (P = .008); similar analysis by metabolic syndrome group found a significant difference only in the -MetS group (P = .018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT (P = .007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states. Conclusion: Humans with the OPN -66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.
AB - Background: Osteopontin (OPN)-transgenic mice exhibit increased carotid artery intima-media thickness (CIMT), smooth muscle cell proliferation, and atheroma formation. Methods: An association of the human T-66G promoter variant with CIMT was examined in Caucasian adults grouped according to metabolic syndrome criteria: present (+MetS; n = 70) or absent (-MetS; n = 70). Results: The G-allele frequency was 22%. For the entire cohort, the G group (TG and GG) was associated with significantly lower age-adjusted and gender-adjusted CIMT compared with the TT group (P = .008); similar analysis by metabolic syndrome group found a significant difference only in the -MetS group (P = .018). Stepwise multivariate regression showed that after age and waist circumference, the T-66G variant was the next most predictive of CIMT (P = .007). These data suggest that in a normoglycemic environment, human vascular OPN gene expression contributes to arterial structure, an effect diminished in dysmetabolic states. Conclusion: Humans with the OPN -66 TT genotype, particularly those without metabolic syndrome, exhibit thicker CIMT.
KW - Arteriosclerosis
KW - Carotid arteries
KW - Genetics
KW - Growth substances
KW - Metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=47649121931&partnerID=8YFLogxK
U2 - 10.1016/j.echo.2008.02.005
DO - 10.1016/j.echo.2008.02.005
M3 - Article
C2 - 18406574
AN - SCOPUS:47649121931
SN - 0894-7317
VL - 21
SP - 954
EP - 960
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 8
ER -