Osteogenic constituents from Pterospermum acerifolium Willd. flowers

Preety Dixit, Mohd Parvez Khan, Gaurav Swarnkar, N. Chattopadhyay, Rakesh Maurya

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Phytochemical investigation of ethanol extracts of the Pterospermum acerifolium flowers led to the isolation and identification of two new flavones, 4′-(2-methoxy-4-(1,2,3-trihydroxypropyl) phenoxy luteolin (1) and 5,7,3′-trihydroxy-6-O-β-d-glucopyranosyl flavone (2), and one new lactone, 3,5-dihydroxyfuran-2(5H)-one (3) along with 14 known compounds (4-17). The structure of compounds 1-17 was established based on MS, 1D and 2D NMR, spectroscopic analysis. Eight of these compounds (1-6, 8 and 9) were assessed for osteogenic activity by using primary cultures of rat osteoblast. The compounds 1, 3 and 4 significantly stimulated osteoblast differentiation and mineralization as evident from a marked increase in expression of alkaline phosphatase and alizarin red-S staining of osteoblasts.

Original languageEnglish
Pages (from-to)4617-4621
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number15
DOIs
StatePublished - Aug 1 2011
Externally publishedYes

Keywords

  • Osteoblast differentiation
  • Pterospermin A
  • Pterospermin B
  • Pterospermin C
  • Pterospermum acerifolium

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