TY - JOUR
T1 - Osteoclast motility
T2 - Putting the brakes on bone resorption
AU - Novack, Deborah V.
AU - Faccio, Roberta
N1 - Funding Information:
The authors wish to thank Paulette Shubert for assistance with figure and manuscript preparation, as well as support from the NIH, AR52921 (to RF) and AR052705 (to DVN), and the Children's Discovery Institute (MD-II-2009-179 to RF and DVN).
PY - 2011/1
Y1 - 2011/1
N2 - As the skeleton ages, the balanced formation and resorption of normal bone remodeling is lost, and bone loss predominates. The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and cytoskeletal reorganization is critical. Podosomes, highly dynamic actin structures, mediate osteoclast motility. Resorbing osteoclasts form a related actin complex, the sealing zone, which provides the boundary for the resorptive microenvironment. Similar to podosomes, the sealing zone rearranges itself to allow continuous resorption while the cell is moving. The major adhesive protein controlling the cytoskeleton is αvβ3 integrin, which collaborates with the growth factor M-CSF and the ITAM receptor DAP12. In this review, we discuss the signaling complexes assembled by these molecules at the membrane, and their downstream mediators that control OC motility and function via the cytoskeleton.
AB - As the skeleton ages, the balanced formation and resorption of normal bone remodeling is lost, and bone loss predominates. The osteoclast is the specialized cell that is responsible for bone resorption. It is a highly polarized cell that must adhere to the bone surface and migrate along it while resorbing, and cytoskeletal reorganization is critical. Podosomes, highly dynamic actin structures, mediate osteoclast motility. Resorbing osteoclasts form a related actin complex, the sealing zone, which provides the boundary for the resorptive microenvironment. Similar to podosomes, the sealing zone rearranges itself to allow continuous resorption while the cell is moving. The major adhesive protein controlling the cytoskeleton is αvβ3 integrin, which collaborates with the growth factor M-CSF and the ITAM receptor DAP12. In this review, we discuss the signaling complexes assembled by these molecules at the membrane, and their downstream mediators that control OC motility and function via the cytoskeleton.
KW - M-CSF
KW - Migration
KW - Podosome
KW - αvβ3 integrin
UR - http://www.scopus.com/inward/record.url?scp=78650239453&partnerID=8YFLogxK
U2 - 10.1016/j.arr.2009.09.005
DO - 10.1016/j.arr.2009.09.005
M3 - Review article
C2 - 19788940
AN - SCOPUS:78650239453
SN - 1568-1637
VL - 10
SP - 54
EP - 61
JO - Ageing Research Reviews
JF - Ageing Research Reviews
IS - 1
ER -