Bone is a dynamic tissue that continuously undergoes coupled resorption and formation, mediated by osteoclasts and osteoblasts, respectively. This process, called bone remodeling, is a prerequisite for normal skeletal homeostasis throughout life. Bone remodeling is regulated by a variety of factors, such as cytokines, chemokines, hormones, and biochemical stimuli. While the physiological necessity of bone remodeling is incompletely understood, its imbalance often prompts disorders such as postmenopausal osteoporosis and the periarticular bone destruction of inflammatory arthritis. Remodeling also probably maintains structural integrity by replacing effete bone that has a compromised structure with new bone in states of attenuated resorption, and its associated coupled-suppression of formation. This prevents weak bone from accumulating, and prevents the development of fractures.

Original languageEnglish
Title of host publicationOsteoimmunology
Subtitle of host publicationInteractions of the Immune and Skeletal Systems: Second Edition
PublisherElsevier Inc.
Number of pages30
ISBN (Print)9780128005712
StatePublished - 2016


  • Costimulatory receptors
  • Cytoskeleton
  • ITAM
  • Kinase
  • NFATc1
  • Osteoclast
  • Osteoclastogenic


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