Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway

Geoffrey R. Erickson, Farshid Guilak

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca2+]i), and to determine the mechanisms of Ca2+ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca2+]i in chondrocytes.

Original languageEnglish
Title of host publicationAmerican Society of Mechanical Engineers, Bioengineering Division (Publication) BED
PublisherASME
Pages43-44
Number of pages2
Volume44
ISBN (Print)0791816435
StatePublished - Dec 1 1999
EventAdvances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA
Duration: Nov 14 1999Nov 19 1999

Conference

ConferenceAdvances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
CityNashville, TN, USA
Period11/14/9911/19/99

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