Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway

Geoffrey R. Erickson; Farshid Guilak

Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway

Geoffrey R. Erickson, Farshid Guilak

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca²⁺]_i), and to determine the mechanisms of Ca²⁺ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca²⁺]_i in chondrocytes.

Original language	English
Title of host publication	American Society of Mechanical Engineers, Bioengineering Division (Publication) BED
Publisher	ASME
Pages	43-44
Number of pages	2
Volume	44
ISBN (Print)	0791816435
State	Published - Dec 1 1999
Event	Advances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition) - Nashville, TN, USA Duration: Nov 14 1999 → Nov 19 1999

Conference

Conference	Advances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition)
City	Nashville, TN, USA
Period	11/14/99 → 11/19/99

Cite this

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title = "Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway",

abstract = "A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca2+]i), and to determine the mechanisms of Ca2+ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca2+]i in chondrocytes.",

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Erickson, GR & Guilak, F 1999, Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway. in American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. vol. 44, ASME, pp. 43-44, Advances in Heat and Mass Transfer in Biotechnology - 1999 (The ASME International Mechanical Engineering Congress and Exposition), Nashville, TN, USA, 11/14/99.

Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway. / Erickson, Geoffrey R.; Guilak, Farshid.

American Society of Mechanical Engineers, Bioengineering Division (Publication) BED. Vol. 44 ASME, 1999. p. 43-44.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway

AU - Erickson, Geoffrey R.

AU - Guilak, Farshid

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N2 - A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca2+]i), and to determine the mechanisms of Ca2+ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca2+]i in chondrocytes.

AB - A study was carried out to examine the hypothesis that osmotic stress initiates a transient increase in the concentration of intracellular calcium ion ([Ca2+]i), and to determine the mechanisms of Ca2+ mobilization in isolated chondrocytes exposed to hypo- and hyper-osmotic stress. Osmotic stress was determined by performing tests within 12 hrs of isolation. The results indicate that both hypo- and hyper-osmotic result in significant increases and oscillations in [Ca2+]i in chondrocytes.

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BT - American Society of Mechanical Engineers, Bioengineering Division (Publication) BED

PB - ASME

Y2 - 14 November 1999 through 19 November 1999

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Osmotic stress initiates intracellular calcium waves in chondrocytes through extracellular influx and the inositol phosphate pathway

Abstract

Conference

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