Orthostatic stability with intravenous levodopa

Shan H. Siddiqi, Mary L. Creech, Kevin J. Black

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Intravenous levodopa has been used in a multitude of research studies due to its more predictable pharmacokinetics compared to the oral form, which is used frequently as a treatment for Parkinson's disease (PD). Levodopa is the precursor for dopamine, and intravenous dopamine would strongly affect vascular tone, but peripheral decarboxylase inhibitors are intended to block such effects. Pulse and blood pressure, with orthostatic changes, were recorded before and after intravenous levodopa or placebo-after oral carbidopa-in 13 adults with a chronic tic disorder and 16 tic-free adult control subjects. Levodopa caused no statistically or clinically significant changes in blood pressure or pulse. These data add to previous data that support the safety of i.v. levodopa when given with adequate peripheral inhibition of DOPA decarboxylase.

Original languageEnglish
Article number1198
JournalPeerJ
Volume2015
Issue number8
DOIs
StatePublished - Jan 1 2015

Keywords

  • Blood pressure
  • Carbidopa
  • Heart rate
  • Intravenous
  • Levodopa
  • Randomized controlled trial
  • Tourette syndrome

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