Orthograde and retrograde axonal transport of dopamine-β-hydroxylase in ileal mesenteric nerves of rats with chronic streptozotocin diabetes

Robert E. Schmidt, Christopher W. Modert, Gary G. Grabau

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Rats with chronic streptozotocin-induced diabetes develop a neuropathy involving the ileal mesenteric nerves. Distal portions of these postganglionic sympathetic axons develop markedly dilated, dopamine-β-hydroxylase (DBH)-containing dystrophic swellings. These findings led us to develop a quantitative method to examine orthograde and retrograde axonal transport of DBH in ileal mesenteric nerves. Surprisingly, no significant alteration in orthograde or retrograde axonal transport of DBH was identified.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalBrain Research
Volume401
Issue number1
DOIs
StatePublished - Jan 13 1987

Keywords

  • Autonomic (sympathetic) neuropathy
  • Axonal transport
  • Diabetes
  • Dopamine-β-hydroxylase
  • Neuroaxonal dystrophy

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