Orlistat in the treatment of NASH: A case series

Stephen A. Harrison, Sanjay Ramrakhiani, Elizabeth M. Brunt, Maan A. Anbari, Cherise Cortese, Bruce R. Bacon

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Nonalcoholic steatohepatitis is now recognized as a common chronic liver disorder. Up to 16% of affected patients may progress to cirrhosis. The incidence and prevalence of this disease are noted to be increasing, in parallel with the nationwide increase in obesity and diabetes. Treatment options for these patients remain quite limited, however. Weight reduction has been advocated, but there are little data to support this practice, as most patients are unable to comply with the proper dietary modifications. We report three obese patients with biopsy-proven nonalcoholic steatohepatitis treated for 6-12 months with a weight reduction medication, orlistat, who lost between 22-42 lb, and had significant clinical and histopathological improvement on follow-up.

Original languageEnglish
Pages (from-to)926-930
Number of pages5
JournalAmerican Journal of Gastroenterology
Issue number4
StatePublished - Apr 1 2003


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