Origin, maturation and antigen presenting function of dendritic cells

Marina Cella, Federica Sallusto, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

1152 Scopus citations

Abstract

Dendritic cells are cells specialized for antigen capture, migration and T cell stimulation. Recent advances have been made in understanding their origin, their heterogeneity, the mechanism of antigen uptake, and the signals that induce their migration and maturation into immunostimulatory antigen-presenting cells. Dendritic cells represent the natural adjuvants for T cell responses and their therapeutic exploitation in the near future is foreseen.

Original languageEnglish
Pages (from-to)10-16
Number of pages7
JournalCurrent Opinion in Immunology
Volume9
Issue number1
DOIs
StatePublished - Feb 1997

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