TY - JOUR
T1 - Organization of the gravity-sensing system in zebrafish
AU - Liu, Zhikai
AU - Hildebrand, David G.C.
AU - Morgan, Joshua L.
AU - Jia, Yizhen
AU - Slimmon, Nicholas
AU - Bagnall, Martha W.
N1 - Funding Information:
We thank Drs. Mohini Sengupta, Vamsi Daliparthi and Mr. Saul Bello Rojas for thoughtful critiques of the paper. We are grateful to Drs. Daniel Kerschensteiner, David Schoppik and members from the Schoppik lab for insightful comments. Serial-section EM imaging was performed in part through the use of Washington University Center for Cellular Imaging (WUCCI) supported by Washington University School of Medicine, The Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). This work is supported by funding through the National Institutes of Health (NIH) R01 DC016413 (M.W.B.), EY030623 (J.L.M.), EY029313 (J.L.M.), a Sloan Research Fellowship (M.W.B.), a Fellowship in Neuroscience from the Leon Levy Foundation and a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (D.G.C.H.), an unrestricted grant to the Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness (J.L.M.), and a Research to Prevent Blindness Career Development Award (J.L.M.). M.W.B. is a Pew Biomedical Scholar and a McKnight Foundation Scholar.
Funding Information:
We thank Drs. Mohini Sengupta, Vamsi Daliparthi and Mr. Saul Bello Rojas for thoughtful critiques of the paper. We are grateful to Drs. Daniel Kerschensteiner, David Schoppik and members from the Schoppik lab for insightful comments. Serial-section EM imaging was performed in part through the use of Washington University Center for Cellular Imaging (WUCCI) supported by Washington University School of Medicine, The Children’s Discovery Institute of Washington University and St. Louis Children’s Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). This work is supported by funding through the National Institutes of Health (NIH) R01 DC016413 (M.W.B.), EY030623 (J.L.M.), EY029313 (J.L.M.), a Sloan Research Fellowship (M.W.B.), a Fellowship in Neuroscience from the Leon Levy Foundation and a NARSAD Young Investigator Grant from the Brain and Behavior Research Foundation (D.G.C.H.), an unrestricted grant to the Department of Ophthalmology and Visual Sciences from Research to Prevent Blindness (J.L.M.), and a Research to Prevent Blindness Career Development Award (J.L.M.). M.W.B. is a Pew Biomedical Scholar and a McKnight Foundation Scholar.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized by similar principles. Using serial-section electron microscopy in larval zebrafish, we generated a complete map of the gravity-sensing (utricular) system spanning from the inner ear to the brainstem. We find that both sensory tuning and developmental sequence are organizing principles of vestibular topography. Patterned rostrocaudal innervation from hair cells to afferents creates an anatomically inferred directional tuning map in the utricular ganglion, forming segregated pathways for rostral and caudal tilt. Furthermore, the mediolateral axis of the ganglion is linked to both developmental sequence and neuronal temporal dynamics. Early-born pathways carrying phasic information preferentially excite fast escape circuits, whereas later-born pathways carrying tonic signals excite slower postural and oculomotor circuits. These results demonstrate that vestibular circuits are organized by tuning direction and dynamics, aligning them with downstream motor circuits and behaviors.
AB - Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized by similar principles. Using serial-section electron microscopy in larval zebrafish, we generated a complete map of the gravity-sensing (utricular) system spanning from the inner ear to the brainstem. We find that both sensory tuning and developmental sequence are organizing principles of vestibular topography. Patterned rostrocaudal innervation from hair cells to afferents creates an anatomically inferred directional tuning map in the utricular ganglion, forming segregated pathways for rostral and caudal tilt. Furthermore, the mediolateral axis of the ganglion is linked to both developmental sequence and neuronal temporal dynamics. Early-born pathways carrying phasic information preferentially excite fast escape circuits, whereas later-born pathways carrying tonic signals excite slower postural and oculomotor circuits. These results demonstrate that vestibular circuits are organized by tuning direction and dynamics, aligning them with downstream motor circuits and behaviors.
UR - http://www.scopus.com/inward/record.url?scp=85137103858&partnerID=8YFLogxK
U2 - 10.1038/s41467-022-32824-w
DO - 10.1038/s41467-022-32824-w
M3 - Article
C2 - 36030280
AN - SCOPUS:85137103858
SN - 2041-1723
VL - 13
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 5060
ER -