Organization of the Drosophila Circadian Control Circuit

Michael N. Nitabach, Paul H. Taghert

Research output: Contribution to journalReview articlepeer-review

232 Scopus citations


Molecular genetics has revealed the identities of several components of the fundamental circadian molecular oscillator - an evolutionarily conserved molecular mechanism of transcription and translation that can operate in a cell-autonomous manner. Therefore, it was surprising when studies of circadian rhythmic behavior in the fruit fly Drosophila suggested that the normal operations of circadian clock cells, which house the molecular oscillator, in fact depend on non-cell-autonomous effects - interactions between the clock cells themselves. Here we review several genetic analyses that broadly extend that viewpoint. They support a model whereby the approximately 150 circadian clock cells in the brain of the fly are sub-divided into functionally discrete rhythmic centers. These centers alternatively cooperate or compete to control the different episodes of rhythmic behavior that define the fly's daily activity profile.

Original languageEnglish
Pages (from-to)R84-R93
JournalCurrent Biology
Issue number2
StatePublished - Jan 22 2008


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