Organization and expression of the Drosophila Phe-Met-Arg-Phe-NH2 neuropeptide gene

L. E. Schneider, P. H. Taghert

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


We have studied a Drosophila gene that encodes multiple neuropeptides related to Phe-Met-Arg-Phe-NH2 (FMRFamide). Using a combination of genomic sequencing, Northern blot analysis, primer extensions, and nuclease protection assays, we have described its organization and expression. The results indicate that this Drosophila neuropeptide gene contains two exons separated by an intron of ∼2.5 kilobase pairs, and that its expression is limited to a single predominant RNA species of ∼1.7 kilobases. The FMRFamide gene contains a 5′ untranslated region that is 106 nucleotides long and is encoded in its entirety by exon I. The open reading frame (encoding a 347-amino acid neuropeptide precursor) begins with the first nucleotide of exon II.

Original languageEnglish
Pages (from-to)6890-6895
Number of pages6
JournalJournal of Biological Chemistry
Issue number12
StatePublished - 1990


Dive into the research topics of 'Organization and expression of the Drosophila Phe-Met-Arg-Phe-NH2 neuropeptide gene'. Together they form a unique fingerprint.

Cite this