Organization and Evolution of the Rat Tyrosine Hydroxylase Gene

Elaine R. Brown, George T. Coker, Karen L. O’Malley

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

This report describes the organization of the rat tyrosine hydroxylase (TH) gene and compares its structure with the human phenylalanine hydroxylase gene. Both genes are single copy and contain 13 exons separated by 12 introns. Remarkably, the positions of 10 out of 12 intron/exon boundaries are identical for the two genes. These results support the idea that these hydroxylase genes are members of a gene family which has a common evolutionary origin. We predict that this ancestral gene would have encoded exons similar to those of TH prior to evolutionary drift to other members of this gene family.

Original languageEnglish
Pages (from-to)5208-5212
Number of pages5
JournalBiochemistry
Volume26
Issue number16
DOIs
StatePublished - Jan 1 1987

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