TY - JOUR
T1 - Organising cells into tissues
T2 - New roles for cell adhesion molecules in planar cell polarity
AU - Saburi, Sakura
AU - McNeill, Helen
PY - 2005/10
Y1 - 2005/10
N2 - Planar cell polarity (PCP) is the coordinated organization of cells within the plane of the epithelium, first described in Drosophila. A Frizzled signalling pathway dedicated to PCP (the non-canonical Frizzled pathway) acts through Dishevelled and small G proteins, as does the classical Wnt pathway, but then diverges downstream of Dishevelled. Recent studies have demonstrated a crucial role for several atypical cadherin molecules (Fat, Dachsous and Flamingo) in controlling PCP signalling. Recent work has also indicated that the first sign of PCP during development is the polarized localization of PCP proteins (Frizzled, Flamingo, Dishevelled, etc). Exciting new data reveal that this PCP pathway is conserved to man.
AB - Planar cell polarity (PCP) is the coordinated organization of cells within the plane of the epithelium, first described in Drosophila. A Frizzled signalling pathway dedicated to PCP (the non-canonical Frizzled pathway) acts through Dishevelled and small G proteins, as does the classical Wnt pathway, but then diverges downstream of Dishevelled. Recent studies have demonstrated a crucial role for several atypical cadherin molecules (Fat, Dachsous and Flamingo) in controlling PCP signalling. Recent work has also indicated that the first sign of PCP during development is the polarized localization of PCP proteins (Frizzled, Flamingo, Dishevelled, etc). Exciting new data reveal that this PCP pathway is conserved to man.
UR - http://www.scopus.com/inward/record.url?scp=24644520033&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2005.08.011
DO - 10.1016/j.ceb.2005.08.011
M3 - Review article
C2 - 16099635
AN - SCOPUS:24644520033
SN - 0955-0674
VL - 17
SP - 482
EP - 488
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 5 SPEC. ISS.
ER -