Organ allocation in pediatric renal transplants: Is there an optimal donor?

Susan C. Pitt, Neeta Vachharajani, Maria B. Doyle, Jeffrey A. Lowell, William C. Chapman, Christopher D. Anderson, Surendra Shenoy, Jason R. Wellen

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The 2005 revised allocation scheme for pediatric renal transplantation made the decision of whether to transplant an available living-donor (LD) kidney or use a deceased-donor (DD) kidney controversial. The aim of this study was to examine kidney allograft utilization, sensitization, and outcomes of pediatric transplant recipients. Between January 2000 and December 2009, 91 consecutive pediatric kidney recipients (<20 yr) were transplanted. The LD (n = 38) and DD (n = 53) groups were similar in age, gender, dialysis status at transplant, warm ischemia time, and overall patient survival. LD recipients were more likely to be Caucasian (92 vs. 69%), receive older allografts (39 ± 10 vs. 23 ± 9 yr), and have fewer human leukocyte antigen (HLA) mismatches (3.3 ± 1.6 vs. 4.4 ± 1.5, p < 0.01 for all). Graft survival at one, three, and five yr post-transplant was longer for LD recipients (97%, 91%, 87% vs. DD 89%, 79%, 58%, respectively, p < 0.05). At the time of transplant, 17 (33%) DD recipients had an available LD (mean age 40 yr). A greater proportion of all patients were moderately (PRA 21-79%) sensitized post-transplant (p < 0.05). A multivariable analysis of graft survival indicated that the advantage in LD organs was likely due to fewer HLA mismatched in this group. Nonetheless, LD organs appear to provide optimal outcomes in pediatric renal transplants when considering the risk of becoming sensitized post-transplant complicating later use of the LD kidney.

Original languageEnglish
Pages (from-to)938-944
Number of pages7
JournalClinical Transplantation
Volume27
Issue number6
DOIs
StatePublished - Nov 1 2013

Keywords

  • Deceased donors
  • Living donors
  • Pediatric kidney transplant
  • Sensitization
  • Transplant outcomes

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