Organ aging signatures in the plasma proteome track health and disease

Hamilton Se Hwee Oh, Jarod Rutledge, Daniel Nachun, Róbert Pálovics, Olamide Abiose, Patricia Moran-Losada, Divya Channappa, Deniz Yagmur Urey, Kate Kim, Yun Ju Sung, Lihua Wang, Jigyasha Timsina, Dan Western, Menghan Liu, Pat Kohlfeld, John Budde, Edward N. Wilson, Yann Guen, Taylor M. Maurer, Michael HaneyAndrew C. Yang, Zihuai He, Michael D. Greicius, Katrin I. Andreasson, Sanish Sathyan, Erica F. Weiss, Sofiya Milman, Nir Barzilai, Carlos Cruchaga, Anthony D. Wagner, Elizabeth Mormino, Benoit Lehallier, Victor W. Henderson, Frank M. Longo, Stephen B. Montgomery, Tony Wyss-Coray

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Animal studies show aging varies between individuals as well as between organs within an individual1–4, but whether this is true in humans and its effect on age-related diseases is unknown. We utilized levels of human blood plasma proteins originating from specific organs to measure organ-specific aging differences in living individuals. Using machine learning models, we analysed aging in 11 major organs and estimated organ age reproducibly in five independent cohorts encompassing 5,676 adults across the human lifespan. We discovered nearly 20% of the population show strongly accelerated age in one organ and 1.7% are multi-organ agers. Accelerated organ aging confers 20–50% higher mortality risk, and organ-specific diseases relate to faster aging of those organs. We find individuals with accelerated heart aging have a 250% increased heart failure risk and accelerated brain and vascular aging predict Alzheimer’s disease (AD) progression independently from and as strongly as plasma pTau-181 (ref. 5), the current best blood-based biomarker for AD. Our models link vascular calcification, extracellular matrix alterations and synaptic protein shedding to early cognitive decline. We introduce a simple and interpretable method to study organ aging using plasma proteomics data, predicting diseases and aging effects.

Original languageEnglish
Pages (from-to)164-172
Number of pages9
Issue number7990
StatePublished - Dec 7 2023


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