@article{068608e0e0954a2b82c7f183f98cd1e7,
title = "ORegAnno: An open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation",
abstract = "Motivation: Our understanding of gene regulation is currently limited by our ability to collectively synthesize and catalogue transcriptional regulatory elements stored in scientific literature. Over the past decade, this task has become increasingly challenging as the accrual of biologically validated regulatory sequences has accelerated. To meet this challenge, novel community-based approaches to regulatory element annotation are required. Summary: Here, we present the Open Regulatory Annotation (ORegAnno) database as a dynamic collection of literature-curated regulatory regions, transcription factor binding sites and regulatory mutations (polymorphisms and haplotypes). ORegAnno has been designed to manage the submission, indexing and validation of new annotations from users worldwide. Submissions to ORegAnno are immediately cross-referenced to EnsEMBL, dbSNP, Entrez Gene, the NCBI Taxonomy database and PubMed, where appropriate.",
author = "Montgomery, {S. B.} and Griffith, {O. L.} and Sleumer, {M. C.} and Bergman, {C. M.} and M. Bilenky and Pleasance, {E. D.} and Y. Prychyna and X. Zhang and Jones, {S. J.M.}",
note = "Funding Information: We would like to acknowledge the Wasserman lab (http://www. cisreg.ca/tjkwon/) and James Fickett (http://www.cbil.upenn.edu/ MTIR/HomePage.html) for generously making their regulatory element catalogues publicly available. We thank the ORegAnno users for their continuing efforts to improve this resource through manual curation and record validation. We gratefully acknowledge funding from Genome Canada, Genome British Columbia and the BC Cancer Foundation. S.B.M. was supported by the Natural Sciences and Engineering Research Council (NSERC) and the Michael Smith Foundation for Health Research (MSFHR). O.L.G. was supported by the Canadian Institutes of Health Research (CIHR), NSERC and MSFHR. E.D.P. was supported by CIHR. M.C.S. and S.J.M.J. were supported by MSFHR.Funding to pay the Open Access publication charges for this article was provided by Genome Canada.",
year = "2006",
month = mar,
doi = "10.1093/bioinformatics/btk027",
language = "English",
volume = "22",
pages = "637--640",
journal = "Bioinformatics",
issn = "1367-4803",
number = "5",
}