Oral cavity cancer: Diagnosis and treatment

Corbin D. Jacobs, Michael J. Moravan, Jennifer Choe, Russel Kahmke, Yvonne Mowery, Joseph K. Salama

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


A comprehensive history, thorough head and neck physical examination, and adequate staging are critical to guide optimal locoregional treatment and evaluate for second primaries in patients with oral cavity cancer. A multidisciplinary approach-including head and neck surgery, radiation and medical oncology, pathology, radiology, nursing, dentistry, dietary, speech, and social work-is paramount for optimal management. Early-stage disease is typically treated with surgery alone, but in certain circumstances radiotherapy alone is preferred. Locally advanced disease is generally managed with upfront surgery and postoperative radiotherapy, with concomitant chemotherapy reserved for high-risk features such as positive surgical margins and extranodal extension.

Original languageEnglish
Title of host publicationEncyclopedia of Cancer
Number of pages38
ISBN (Electronic)9780128124857
StatePublished - Jan 1 2018


  • Alveolar ridge
  • Buccal mucosa
  • Chemotherapy
  • Erythroplakia
  • Extranodal extension
  • Floor of mouth
  • Hard palate
  • Human papillomavirus
  • Leukoplakia
  • Lip
  • Oral cavity
  • Oral tongue
  • Radiotherapy
  • Retromolar trigone
  • Surgery
  • Tobacco


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