@article{213e26d0a9374182b575694ec5201593,
title = "Optimizing eligibility criteria and clinical trial conduct to enhance clinical trial participation for primary brain tumor patients",
abstract = "Building on an initiative to enhance clinical trial participation involving the Society for Neuro-Oncology, the Response Assessment in Neuro-Oncology Working Group, patient advocacy groups, clinical trial cooperative groups, and other partners, we evaluate the impact of eligibility criteria and trial conduct on neuro-oncology clinical trial participation. Clinical trials often carry forward eligibility criteria from prior studies that may be overly restrictive and unnecessary and needlessly limit patient accrual. Inclusion and exclusion criteria should be evaluated based on the goals and design of the study and whether they impact patient safety and/or treatment efficacy. In addition, we evaluate clinical trial conduct as a barrier to accrual and discuss strategies to minimize such barriers for neuro-oncology trials.",
keywords = "clinical trials, eligibility, exclusion criteria, inclusion criteria, primary brain tumor",
author = "Lee, {Eudocia Q.} and Lee, {Eudocia Q.} and Michael Weller and Joohee Sul and Bagley, {Stephen J.} and Solmaz Sahebjam and {Van Den Bent}, Martin and Manmeet Ahluwalia and Campian, {Jian L.} and Evanthia Galanis and Gilbert, {Mark R.} and Matthias Holdhoff and Lesser, {Glenn J.} and Lieberman, {Frank S.} and Mehta, {Minesh P.} and Marta Penas-Prado and Schreck, {Karisa C.} and Strowd, {Roy E.} and Vogelbaum, {Michael A.} and Tobias Walbert and Chang, {Susan M.} and Nabors, {L. Burt} and Stuart Grossman and Reardon, {David A.} and Reardon, {David A.} and Wen, {Patrick Y.} and Wen, {Patrick Y.}",
note = "Funding Information: This work was supported by the Adult Brain Tumor Consortium (ABTC) NIH/NCI UM1 CA137443. Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
month = may,
day = "15",
doi = "10.1093/neuonc/noaa015",
language = "English",
volume = "22",
pages = "601--612",
journal = "Neuro-Oncology",
issn = "1522-8517",
number = "5",
}