Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

  • John G. Doench
  • , Nicolo Fusi
  • , Meagan Sullender
  • , Mudra Hegde
  • , Emma W. Vaimberg
  • , Katherine F. Donovan
  • , Ian Smith
  • , Zuzana Tothova
  • , Craig Wilen
  • , Robert Orchard
  • , Herbert W. Virgin
  • , Jennifer Listgarten
  • , David E. Root

Research output: Contribution to journal › Article › peer-review

3177 Scopus citations

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Agricultural and Biological Sciences

Biochemistry, Genetics and Molecular Biology