TY - JOUR
T1 - Optimized cardiac functional MRI of small-animal models of cancer radiation therapy
AU - Ibrahim, El Sayed H.
AU - Baruah, Dhiraj
AU - Budde, Matthew
AU - Rubenstein, Jason
AU - Frei, Anne
AU - Schlaak, Rachel
AU - Gore, Elizabeth
AU - Bergom, Carmen
N1 - Funding Information:
The authors have no relevant disclosures/conflict of interest to declare. C.B. received research funding from Innovation Pathways, Palo Alto, CA, ending in February 2020.
Funding Information:
This work was supported by the Daniel M. Soref Charitable Trust, Center for Imaging Research, Medical College of Wisconsin, USA (E.H.I. and C.B.). This work was supported by NIHNHLBI 1R01HL147884, Bethesda, Maryland, USA (C.B.). Additional support was provided by the Mary Kay Foundation Award Grant No. 017-29, Dallas, Texas, USA (C.B.), Susan G. Komen® Grant CCR17483233, Dallas, Texas, USA (C.B.), the Nancy Laning Sobczak, PhD, Breast Cancer ResearchAward (C.B.), Milwaukee, Wisconsin, USA, the Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, USA (C.B.), the Michael H. Keelan, Jr. MD, Research Foundation Grant (C.B.), Milwaukee, Wisconsin, USA, and the Cardiovascular Center at the Medical College of Wisconsin, Milwaukee, Wisconsin, USA (C.B.).
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/11
Y1 - 2020/11
N2 - Cardiac MRI of small animal models of cancer radiation therapy (RT) is a valuable tool for studying the effect of RT on the heart. However, standard cardiac MRI exams require long scanning times, which is challenging for sick animals that may not survive extended periods of imaging under anesthesia. The purpose of this study is to develop an optimized, fast MRI exam for comprehensive cardiac functional imaging of small-animal models of cancer RT. Ten adult female rats (2 non-irradiated and 8 irradiated) were scanned using the developed exam. Optimal imaging parameters were determined, which minimized scanning time while ensuring measurement accuracy and avoiding imaging artifacts. This optimized, fast MRI exam lasted for 30 min, which was tolerated by all animals. EF was normal in all imaged rats, although it was significantly increased in the irradiated rats, which also showed ventricular hypertrophy. However, myocardial strain was significantly reduced in the irradiated rats. In conclusion, a fast MRI exam has been developed for comprehensive cardiac functional imaging of rats in 30 min, with optimized imaging parameters to ensure accurate measurements and tolerance by irradiated rats. The generated strain measurements provide an early marker of regional cardiac dysfunction before global function is affected.
AB - Cardiac MRI of small animal models of cancer radiation therapy (RT) is a valuable tool for studying the effect of RT on the heart. However, standard cardiac MRI exams require long scanning times, which is challenging for sick animals that may not survive extended periods of imaging under anesthesia. The purpose of this study is to develop an optimized, fast MRI exam for comprehensive cardiac functional imaging of small-animal models of cancer RT. Ten adult female rats (2 non-irradiated and 8 irradiated) were scanned using the developed exam. Optimal imaging parameters were determined, which minimized scanning time while ensuring measurement accuracy and avoiding imaging artifacts. This optimized, fast MRI exam lasted for 30 min, which was tolerated by all animals. EF was normal in all imaged rats, although it was significantly increased in the irradiated rats, which also showed ventricular hypertrophy. However, myocardial strain was significantly reduced in the irradiated rats. In conclusion, a fast MRI exam has been developed for comprehensive cardiac functional imaging of rats in 30 min, with optimized imaging parameters to ensure accurate measurements and tolerance by irradiated rats. The generated strain measurements provide an early marker of regional cardiac dysfunction before global function is affected.
KW - Cardiac function
KW - Heart
KW - Radiation therapy
KW - Small animal model
KW - Strain
UR - http://www.scopus.com/inward/record.url?scp=85090239163&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2020.08.020
DO - 10.1016/j.mri.2020.08.020
M3 - Article
C2 - 32866598
AN - SCOPUS:85090239163
SN - 0730-725X
VL - 73
SP - 130
EP - 137
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
ER -