Optimized cardiac functional MRI of small-animal models of cancer radiation therapy

El Sayed H. Ibrahim, Dhiraj Baruah, Matthew Budde, Jason Rubenstein, Anne Frei, Rachel Schlaak, Elizabeth Gore, Carmen Bergom

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Cardiac MRI of small animal models of cancer radiation therapy (RT) is a valuable tool for studying the effect of RT on the heart. However, standard cardiac MRI exams require long scanning times, which is challenging for sick animals that may not survive extended periods of imaging under anesthesia. The purpose of this study is to develop an optimized, fast MRI exam for comprehensive cardiac functional imaging of small-animal models of cancer RT. Ten adult female rats (2 non-irradiated and 8 irradiated) were scanned using the developed exam. Optimal imaging parameters were determined, which minimized scanning time while ensuring measurement accuracy and avoiding imaging artifacts. This optimized, fast MRI exam lasted for 30 min, which was tolerated by all animals. EF was normal in all imaged rats, although it was significantly increased in the irradiated rats, which also showed ventricular hypertrophy. However, myocardial strain was significantly reduced in the irradiated rats. In conclusion, a fast MRI exam has been developed for comprehensive cardiac functional imaging of rats in 30 min, with optimized imaging parameters to ensure accurate measurements and tolerance by irradiated rats. The generated strain measurements provide an early marker of regional cardiac dysfunction before global function is affected.

Original languageEnglish
Pages (from-to)130-137
Number of pages8
JournalMagnetic Resonance Imaging
Volume73
DOIs
StatePublished - Nov 2020

Keywords

  • Cardiac function
  • Heart
  • Radiation therapy
  • Small animal model
  • Strain

Fingerprint

Dive into the research topics of 'Optimized cardiac functional MRI of small-animal models of cancer radiation therapy'. Together they form a unique fingerprint.

Cite this