Optimization of optode arrangements for diffuse optical tomography: A singular-value analysis

J. P. Culver, V. Ntziachristos, M. J. Holboke, A. G. Yodh

Research output: Contribution to journalArticlepeer-review

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Abstract

We develope a method to optimize the resolution of diffuse optical tomographic instruments. Singular-value analysis of the tomographic weight matrix associated with specific data types, geometries, and optode arrangements is shown to provide a measure of image resolution. We achieve optimization of device configuration by monitoring the resolution measure described. We introduce this idea and demonstrate its utility by optimizing the spatial sampling interval and field-of-view parameters in the parallel-plane transmission geometry employed for diffuse optical breast imaging. We also compare resolution in transmission and remission geometries.

Original languageEnglish
Pages (from-to)701-703
Number of pages3
JournalOptics Letters
Volume26
Issue number10
DOIs
StatePublished - May 15 2001

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