The recently developed total-body positron emission tomography (PET) scanner can capture total-body tracer kinetics, thus enabling systems imaging of multiple organs and interactions between organs, simultaneously. However, their prohibitive cost and sitting requirements may present a barrier for widespread adaptation. Most commercial PET scanners have a limited AFOV. To circumvent the limited AFOV, scanner manufacturers have implemented static step and shoot (SSS) protocols to "stitch"images acquired at multiple bed positions into a single total-body image. However, the resulting "total-body"images may not be quantitative depending on the kinetics of the tracers, thus biasing quantitative imaging comparisons. We propose a dynamic step and shoot (DSS) protocol with 2sec temporal sampling to pursue a continuous imaging protocol with different acquisition times in different bed positions for each pass through the torso. D-optimal criterion was used to optimize the acquisition protocol using a simulated annealing algorithm. The overall approach is illustrated in estimating parameters of a reversible two-compartment PET kinetic model for key organs in the torso. The intra- and inter-subject performance of the optimal DSS (ODSS) protocol was compared with the SSS protocol in terms of bias and variability and in comparison to the total-body (TB) protocol. The simulations suggest that the proposed ODSS protocol outperforms the conventional SSS protocol in both intra- and inter-subject parameter accuracy and precision tests and generates similar macro-parameter estimates compared to the TB scanner. Overall, we demonstrate that we can achieve an optimal temporal imaging schedule to support quantitative TB systems imaging.

Original languageEnglish
Title of host publicationMedical Imaging 2023
Subtitle of host publicationPhysics of Medical Imaging
EditorsLifeng Yu, Rebecca Fahrig, John M. Sabol
ISBN (Electronic)9781510660311
StatePublished - 2023
EventMedical Imaging 2023: Physics of Medical Imaging - San Diego, United States
Duration: Feb 19 2023Feb 23 2023

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2023: Physics of Medical Imaging
Country/TerritoryUnited States
CitySan Diego


  • 2-tissue compartment model
  • Multi-organ dynamic PET imaging
  • Step and shoot protocol


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