Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model

Chenghung Yeh, Song Hu, Jinyang Liang, Lei Li, Brian Soetikno, Zhi Hong Lu, Rebecca E. Sohn, Konstantin Maslov, Jeffrey M. Arbeit, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

We propose using noninvasive longitudinal optical-resolution photoacoustic microscopy (L-ORPAM) to quantify blood flow flux, oxygen saturation (sO2), and thereby the metabolic rate of oxygen (MRO2), for a renal tumor model in the same mouse over weeks to months. Experiments showed that the sO2 difference between the artery and vein decreased greatly due to the arteriovenous shunting effect during tumor growth. Moreover, hypermetabolism was exhibited by an increase in MRO2.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2015
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781628414134
DOIs
StatePublished - Jan 1 2015
EventPhotons Plus Ultrasound: Imaging and Sensing 2015 - San Francisco, United States
Duration: Feb 8 2015Feb 10 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume9323
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2015
CountryUnited States
CitySan Francisco
Period02/8/1502/10/15

Keywords

  • Cancer
  • Metabolic rate of oxygen
  • Optical-resolution
  • Oxygen saturation
  • Photoacoustic microscopy
  • Tumor

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  • Cite this

    Yeh, C., Hu, S., Liang, J., Li, L., Soetikno, B., Lu, Z. H., Sohn, R. E., Maslov, K., Arbeit, J. M., & Wang, L. V. (2015). Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model. In A. A. Oraevsky, & L. V. Wang (Eds.), Photons Plus Ultrasound: Imaging and Sensing 2015 [93233H] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9323). SPIE. https://doi.org/10.1117/12.2082948