Optical-resolution photoacoustic microscopy of ischemic stroke

Song Hu, Ernie Gonzales, Brian Soetikno, Enhao Gong, Ping Yan, Konstantin Maslov, Jin Moo Lee, Lihong V. Wang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

25 Scopus citations


A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO 2) values of feeder arteries and draining veins within the stroke core region dropped ∼10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO 2 increased above the baseline value by ∼7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2011
StatePublished - 2011
EventPhotons Plus Ultrasound: Imaging and Sensing 2011 - San Francisco, CA, United States
Duration: Jan 23 2011Jan 25 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2011
Country/TerritoryUnited States
CitySan Francisco, CA


  • Hemoglobin oxygen saturation
  • Ischemic stroke
  • Optical-resolution photoacoustic microscopy
  • Oxygen extraction fraction
  • Vascular anatomy


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