@inproceedings{31f7b5d2bd7d48778de49ac0de52b779,
title = "Optical-resolution photoacoustic microscopy of ischemic stroke",
abstract = "A major obstacle in understanding the mechanism of ischemic stroke is the lack of a tool to noninvasively or minimally invasively monitor cerebral hemodynamics longitudinally. Here, we applied optical-resolution photoacoustic microscopy (OR-PAM) to longitudinally study ischemic stroke induced brain injury in a mouse model with transient middle cerebral artery occlusion (MCAO). OR-PAM showed that, during MCAO, the average hemoglobin oxygen saturation (sO 2) values of feeder arteries and draining veins within the stroke core region dropped ∼10% and ~34%, respectively. After reperfusion, arterial sO2 recovered back to the baseline; however, the venous sO 2 increased above the baseline value by ∼7%. Thereafter, venous sO2 values were close to the arterial sO2 values, suggesting eventual brain tissue infarction.",
keywords = "Hemoglobin oxygen saturation, Ischemic stroke, Optical-resolution photoacoustic microscopy, Oxygen extraction fraction, Vascular anatomy",
author = "Song Hu and Ernie Gonzales and Brian Soetikno and Enhao Gong and Ping Yan and Konstantin Maslov and Lee, {Jin Moo} and Wang, {Lihong V.}",
year = "2011",
month = feb,
day = "10",
doi = "10.1117/12.874366",
language = "English",
isbn = "9780819484369",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
}