@inproceedings{ad5fc0fc2f8e48ca907776e8aae504eb,
title = "Optical-resolution photoacoustic microscopy of angiogenesis in a transgenic mouse model",
abstract = "A major obstacle in studying angiogenesis is the inability to noninvasively image neovascular development in an individual animal. We applied optical-resolution photoacoustic microscopy (OR-PAM) to determine the kinetics of hypoxia-inducible factor-1 (HIF-1)-mediated angiogenesis in a transgenic mouse model. During continuous 30-day activation of HIF-1α, we used OR-PAM to monitor alterations in microvasculature in transgenic mice compared to nontransgenic mice. OR-PAM has demonstrated the potential to precisely monitor antiangiogenic therapy of human cancers, allowing for rapid determinations of therapeutic efficacy or resistance.",
keywords = "Angiogenesis, Chronic imaging, HIF-1α, Optical-resolution photoacoustic microscopy",
author = "Song Hu and Sunday Oladipupo and Junjie Yao and Santeford, \{Andrea C.\} and Konstantin Maslov and Joanna Kovalski and Arbeit, \{Jeffrey M.\} and Wang, \{Lihong V.\}",
year = "2010",
month = feb,
day = "11",
doi = "10.1117/12.841177",
language = "English",
isbn = "9780819479600",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",
}