@inproceedings{36acb80eb3e844b4898c0e8961abbc69,
title = "Optical-resolution photoacoustic microscopy of amyloid-β deposits in vivo",
abstract = "Advances in high-resolution imaging have permitted microscopic observations within the brains of living animals. Applied to Alzheimer's disease (AD) mouse models, multiphoton microscopy has opened a new window to study the real-time appearance and growth of amyloid plaques. Here, we report an alternative technology-optical-resolution photoacoustic microscopy (OR-PAM)-for in vivo imaging of amyloid plaques in a transgenic AD mouse model. In vivo validation using multiphoton microscopy shows that OR-PAM has sufficient sensitivity and spatial resolution to identify amyloid plaques in living brains. In addition, with dual-wavelength OR-PAM, the three-dimensional morphology of amyloid plaques and the surrounding microvasculature are imaged simultaneously through a cranial window. In vivo transcranial OR-PAM imaging of amyloid plaques is highly likely once the imaging parameters are optimized.",
keywords = "Alzheimer's disease, Amyloid-β, Dual contrast, Optical-resolution photoacoustic microscopy",
author = "Song Hu and Ping Yan and Konstantin Maslov and Lee, {Jin Moo} and Wang, {Lihong V.}",
year = "2010",
doi = "10.1117/12.843919",
language = "English",
isbn = "9780819479600",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2010 ; Conference date: 24-01-2010 Through 26-01-2010",
}