@article{84a419e6e4d747ad963ee27e6e325f35,
title = "Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects",
abstract = "We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO 2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF ASL-MRI, n=12) cross-validate rCBFDCS against rCBF ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.",
keywords = "Cerebral blood flow, Congenital heart disease, Diffuse correlation spectroscopy, Diffuse optics, Near-infrared spectroscopy, Pediatrics",
author = "Turgut Durduran and Chao Zhou and Buckley, {Erin M.} and Kim, {Meeri N.} and Guoqiang Yu and Regine Choe and {William Gaynor}, J. and Spray, {Thomas L.} and Durning, {Suzanne M.} and Mason, {Stefanie E.} and Montenegro, {Lisa M.} and Nicolson, {Susan C.} and Zimmerman, {Robert A.} and Putt, {Mary E.} and Jiongjiong Wang and Greenberg, {Joel H.} and Detre, {John A.} and Yodh, {Arjun G.} and Licht, {Daniel J.}",
note = "Funding Information: This study was supported by NIH Grant Nos. HL-57835, NS-60653, NS-45839, RR-02305, EB-007610, HL-077699, HD-26979, and NS-52380; Thrasher Research Fund (NR 0016); Fundaci{\'o} Cellex Barcelona; and June and Steve Wolfson Family Foundation. We acknowledge invaluable assistance from Dalton Hance and staff of the MRI facilities at Children{\textquoteright}s Hospital of Philadelphia.",
year = "2010",
month = may,
doi = "10.1117/1.3425884",
language = "English",
volume = "15",
journal = "Journal of biomedical optics",
issn = "1083-3668",
number = "3",
}