We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO 2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF ASL-MRI, n=12) cross-validate rCBFDCS against rCBF ASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRSDCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
- Cerebral blood flow
- Congenital heart disease
- Diffuse correlation spectroscopy
- Diffuse optics
- Near-infrared spectroscopy