Abstract
We generated transgenic mice expressing firefly (Photinus pyralis) luciferase (luc) under the control of the mouse insulin 1 promoter (MIP). The mice have normal glucose tolerance and pancreatic islet architecture. The luciferase-expressing beta cells can be readily visualized in living mice using whole-body bioluminescent imaging. The MIP-luc transgenic mice may be useful for monitoring changes in beta cell function or mass in living animals with normal or altered metabolic states.
Original language | English |
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Pages (from-to) | 80-86 |
Number of pages | 7 |
Journal | Genesis |
Volume | 43 |
Issue number | 2 |
DOIs | |
State | Published - Oct 2005 |
Keywords
- Beta cell
- Firefly luciferase
- Imaging
- Insulin
- Transgenic