Optical imaging of mammary and prostate tumors in living animals using a synthetic near infrared zinc(II)-dipicolylamine probe for anionic cell surfaces

Bryan A. Smith, Walter J. Akers, W. Matthew Leevy, Andrew J. Lampkins, Shuzhang Xiao, William Wolter, Mark A. Suckow, Samuel Achilefu, Bradley D. Smith

Research output: Contribution to journalArticle

138 Scopus citations

Abstract

(Figure Presented) In vivo optical imaging shows that a fluorescent imaging probe, comprised of a near-infrared fluorophore attached to an affinity group containing two zinc(II)-dipicolylamine (Zn-DPA) units, targets prostate and mammary tumors in two different xenograft animal models. The tumor selectivity is absent with control fluorophores whose structures do not have appended Zn-DPA targeting ligands. Ex vivo biodistribution and histological analyses indicate that the probe is targeting the necrotic regions of the tumors, which is consistent with in vitro microscopy showing selective targeting of the anionic membrane surfaces of dead and dying cells.

Original languageEnglish
Pages (from-to)67-69
Number of pages3
JournalJournal of the American Chemical Society
Volume132
Issue number1
DOIs
StatePublished - Jan 13 2010

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