TY - JOUR
T1 - Optical imaging in cancer research
T2 - Basic principles, tumor detection, and therapeutic monitoring
AU - Solomon, Metasebya
AU - Liu, Yang
AU - Berezin, Mikhail Y.
AU - Achilefu, Samuel
PY - 2011/7
Y1 - 2011/7
N2 - Accurate and rapid detection of diseases is of great importance for assessing the molecular basis of pathogenesis, preventing the onset of complications, and implementing a tailored therapeutic regimen. The ability of optical imaging to transcend wide spatial imaging scales ranging from cells to organ systems has rejuvenated interest in using this technology for medical imaging. Moreover, optical imaging has at its disposal diverse contrast mechanisms for distinguishing normal from pathologic processes and tissues. To accommodate these signaling strategies, an array of imaging techniques has been developed. Importantly, light absorption, and emission methods, as well as hybrid optical imaging approaches are amenable to both small animal and human studies. Typically, complex methods are needed to extract quantitative data from deep tissues. This review focuses on the development of optical imaging platforms, image processing techniques, and molecular probes, as well as their applications in cancer diagnosis, staging, and monitoring therapeutic response.
AB - Accurate and rapid detection of diseases is of great importance for assessing the molecular basis of pathogenesis, preventing the onset of complications, and implementing a tailored therapeutic regimen. The ability of optical imaging to transcend wide spatial imaging scales ranging from cells to organ systems has rejuvenated interest in using this technology for medical imaging. Moreover, optical imaging has at its disposal diverse contrast mechanisms for distinguishing normal from pathologic processes and tissues. To accommodate these signaling strategies, an array of imaging techniques has been developed. Importantly, light absorption, and emission methods, as well as hybrid optical imaging approaches are amenable to both small animal and human studies. Typically, complex methods are needed to extract quantitative data from deep tissues. This review focuses on the development of optical imaging platforms, image processing techniques, and molecular probes, as well as their applications in cancer diagnosis, staging, and monitoring therapeutic response.
KW - Activatable probes
KW - Diffuse optical tomography
KW - Fluorescence lifetime
KW - Image reconstruction
KW - Molecular probe
KW - Near-infrared
KW - Photoacoustic imaging
KW - Spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=79960504078&partnerID=8YFLogxK
U2 - 10.1159/000327655
DO - 10.1159/000327655
M3 - Review article
C2 - 21757928
AN - SCOPUS:79960504078
SN - 1011-7571
VL - 20
SP - 397
EP - 415
JO - Medical Principles and Practice
JF - Medical Principles and Practice
IS - 5
ER -