TY - JOUR
T1 - Optical Coherence Tomography for Brain Imaging and Developmental Biology
AU - Men, Jing
AU - Huang, Yongyang
AU - Solanki, Jitendra
AU - Zeng, Xianxu
AU - Alex, Aneesh
AU - Jerwick, Jason
AU - Zhang, Zhan
AU - Tanzi, Rudolph E.
AU - Li, Airong
AU - Zhou, Chao
N1 - Funding Information:
This work was supported in part by Lehigh University Start-up Fund, under NIH Grants R00EB010071, R15EB019704, R21EY 026380, R03AR063271, R01MH060009, and R01AG014713, and under NSF Grant 1455613. J. Men and Y. Huang contributed equally to this paper.
Publisher Copyright:
© 2016 IEEE.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its noninvasiveness nature, OCT enables longitudinal imaging of developing specimens in vivo without potential damage from surgical operation, tissue fixation and processing, and staining with exogenous contrast agents. In this paper, various OCT applications in brain imaging and developmental biology are reviewed, with a particular focus on imaging heart development. In addition, we report findings on the effects of a circadian gene ( Clock) and high-fat diet on heart development in Drosophila melanogaster. These findings contribute to our understanding of the fundamental mechanisms connecting circadian genes and obesity to heart development and cardiac diseases.
AB - Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its noninvasiveness nature, OCT enables longitudinal imaging of developing specimens in vivo without potential damage from surgical operation, tissue fixation and processing, and staining with exogenous contrast agents. In this paper, various OCT applications in brain imaging and developmental biology are reviewed, with a particular focus on imaging heart development. In addition, we report findings on the effects of a circadian gene ( Clock) and high-fat diet on heart development in Drosophila melanogaster. These findings contribute to our understanding of the fundamental mechanisms connecting circadian genes and obesity to heart development and cardiac diseases.
KW - Biological systems
KW - Biomedical optical imaging
KW - Brain
KW - Cardiovascular system and Optical tomography
UR - http://www.scopus.com/inward/record.url?scp=84968919502&partnerID=8YFLogxK
U2 - 10.1109/JSTQE.2015.2513667
DO - 10.1109/JSTQE.2015.2513667
M3 - Article
AN - SCOPUS:84968919502
SN - 1077-260X
VL - 22
SP - 120
EP - 132
JO - IEEE Journal of Selected Topics in Quantum Electronics
JF - IEEE Journal of Selected Topics in Quantum Electronics
IS - 4
M1 - 7368884
ER -