Optical coherence microscopy

Aaron D. Aguirre; Chao Zhou; Hsiang Chieh Lee; Osman O. Ahsen; James G. Fujimoto

doi:10.1007/978-3-319-06419-2_29

Optical coherence microscopy

Aaron D. Aguirre, Chao Zhou, Hsiang Chieh Lee, Osman O. Ahsen, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

23 Scopus citations

Abstract

Cellular imaging of human tissues remains an important advance for many clinical applications of optical coherence tomography (OCT). Imaging cells with traditional OCT systems has not been possible due to the limited transverse resolution of such techniques. Optical coherence microscopy (OCM) refers to OCT methods that achieve high transverse resolution to visualize cells and subcellular features. This chapter provides a comprehensive discussion of the rationale for cellular imaging in human tissues as well as a review of the key technological advances required to achieve it. Time domain and Fourier domain OCM approaches are described with an emphasis on state of the art system designs, including miniaturized endoscopic imaging probes. Clinical applications are discussed and multiple examples of cellular imaging in human tissues are provided.

Original language	English
Title of host publication	Optical Coherence Tomography
Subtitle of host publication	Technology and Applications, Second Edition
Publisher	Springer International Publishing
Pages	865-911
Number of pages	47
ISBN (Electronic)	9783319064192
ISBN (Print)	9783319064185
DOIs	https://doi.org/10.1007/978-3-319-06419-2_29
State	Published - Jan 1 2015

Keywords

Cellular imaging
Confocal microscopy
Endoscopy
Femtosecond laser
Optical coherence microscopy

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10.1007/978-3-319-06419-2_29

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abstract = "Cellular imaging of human tissues remains an important advance for many clinical applications of optical coherence tomography (OCT). Imaging cells with traditional OCT systems has not been possible due to the limited transverse resolution of such techniques. Optical coherence microscopy (OCM) refers to OCT methods that achieve high transverse resolution to visualize cells and subcellular features. This chapter provides a comprehensive discussion of the rationale for cellular imaging in human tissues as well as a review of the key technological advances required to achieve it. Time domain and Fourier domain OCM approaches are described with an emphasis on state of the art system designs, including miniaturized endoscopic imaging probes. Clinical applications are discussed and multiple examples of cellular imaging in human tissues are provided.",

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AU - Zhou, Chao

AU - Lee, Hsiang Chieh

AU - Ahsen, Osman O.

AU - Fujimoto, James G.

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Optical coherence microscopy

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