Optic nerve diffusion tensor imaging parameters and their correlation with optic disc topography and disease severity in adult glaucoma patients and controls

Sidney T. Chang, Junqian Xu, Kathryn Trinkaus, Melike Pekmezci, Stella N. Arthur, Sheng Kwei Song, Edward M. Barnett

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Purpose: To evaluate optic nerve diffusion tensor imaging (DTI) parameters in glaucoma patients and controls, and to correlate DTI parameters with the rim area obtained with Heidelberg retina tomography (HRT) and with the severity of glaucomatous damage using the Glaucoma Staging System.

Design: Pilot study.

Methods: Twenty-seven patients with glaucoma and 12 control subjects underwent DTI and HRT imaging. Main outcome measures included: fractional anisotropy, mean diffusivity, axial diffusivity, radial diffusivity, HRT rim area, and Glaucoma Staging System stage.

Conclusions: DTI may be a useful technique for detection and evaluation of glaucomatous damage in the optic nerve, particularly for patients in whom conventional imaging and perimetry are not possible. Future studies are needed to evaluate how DTI parameters change longitudinally with glaucomatous damage within the visual pathways and address cerebrospinal fluid partial volume effects in diffusion tensor quantification, especially for patients with advanced glaucoma stage.

Results: In group comparison, mean diffusivity (1.33 vs. 0.91 μm2/ms, P=0.0002), axial diffusivity (1.70 vs. 1.43 μm2/ms, P=0.036), and radial diffusivity (1.24 vs. 0.71 μm2/ms, P<0.0001) were significantly higher and fractional anisotropy (0.21 vs. 0.44, P<0.0001) was significantly lower in the glaucoma compared with those of control subjects. In glaucoma patients, mean, axial, and radial diffusivities increased and fractional anisotropy decreased as rim area decreases and the Glaucoma stage increased (P<0.05). However, there were no statistically significant differences in the DTI parameters when adjacent pairs of stages were compared (P>0.05).

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalJournal of Glaucoma
Volume23
Issue number8
DOIs
StatePublished - Dec 10 2014

Keywords

  • Diffusion tensor imaging
  • Glaucoma staging system
  • Heidelberg retina tomography

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