@article{0831248c491c488ab7d940261c856211,
title = "Opportunities for the federal government to advance necrotizing enterocolitis research",
abstract = "Background: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in the neonatal ICU with minimal progress in the research. Methods: Federal webpages were queried to look for funding opportunity announcements (FOAs) and to develop lists of funded projects on NEC to identify gaps in NEC-related research topics. Results: Over the past 30 years, the National Institutes of Health (NIH) issued two FOAs to stimulate research on NEC with $4.1 million set aside for the first year of respective funding. We identified 23 recently funded studies of which 18 were research projects, 4 training grants, and 1 conference grant support. Only one grant focused on parent and family engagement in the NICU. Conclusion: There are significant research gaps that can be addressed with adequate funding from the federal government on the prevention and treatment of NEC.",
author = "Gadepalli, {Samir K.} and Jennifer Canvasser and Misty Good and Raju, {Tonse N.K.}",
note = "Funding Information: Investigator-initiated research funded by NIH to support NEC research. Information in this area is difficult to discern using publicly available databases. However, using the NIH RePORTer database, we sought to identify any research funded by NIH for projects related to NEC. We identified 216 annual awards made by various NIH entities between 1985 and 2019 for 65 projects that contained “necrotizing enterocolitis” in the titles. Since NIH funding mechanisms have multiple years of funding, there are more “awards” than projects. For these 216 awards, the NIH entities spent a total of $48,439,181—an average of <$1.5 million per year, which is a tiny fraction of the NIH{\textquoteright}s annual budget of about $33 billion. Among the 65 projects, there were 23 active studies, of which 18 were research projects (R or P), 4 training grants (Ks and Fs), and 1 conference-support grant (R13) (Table 2). Funding Information: BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in the neonatal ICU with minimal progress in the research. METHODS: Federal webpages were queried to look for funding opportunity announcements (FOAs) and to develop lists of funded projects on NEC to identify gaps in NEC-related research topics. RESULTS: Over the past 30 years, the National Institutes of Health (NIH) issued two FOAs to stimulate research on NEC with $4.1 million set aside for the first year of respective funding. We identified 23 recently funded studies of which 18 were research projects, 4 training grants, and 1 conference grant support. Only one grant focused on parent and family engagement in the NICU. CONCLUSION: There are significant research gaps that can be addressed with adequate funding from the federal government on the prevention and treatment of NEC. Funding Information: The NEC Society, in conjunction with University of Michigan Pediatric Surgery, hosted the NEC Symposium in June, 2019 where all the authors were present. The NEC Symposium is supported by a Patient-Centered Outcomes Research Institute (PCORI) Engagement Award. S.K.G. is supported by a grant from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) 1R13HD098853–01. M.G. is supported by the National Institutes of Health R01DK118568 and Pediatric Loan Repayment Program, March of Dimes Foundation Grant No. 5-FY17–79, the Children{\textquoteright}s Discovery Institute of Washington University and St. Louis Children{\textquoteright}s Hospital, and the Department of Pediatrics at Washington University School of Medicine, St. Louis. None of the funding bodies had any role in the manuscript. Publication of this article was sponsored by the Necrotizing Enterocolitis (NEC) Society, Patient-Centered Outcomes Research Institute, and National Institutes of Health Eunice Kennedy Shriver National Institute of Child Health and Human Development. Publisher Copyright: {\textcopyright} 2020, International Pediatric Research Foundation, Inc.",
year = "2020",
month = aug,
day = "1",
doi = "10.1038/s41390-020-1081-5",
language = "English",
volume = "88",
pages = "56--59",
journal = "Pediatric Research",
issn = "0031-3998",
}