TY - JOUR
T1 - Opioid exposure during therapeutic hypothermia and short-term outcomes in neonatal encephalopathy
AU - Children’s Hospitals Neonatal Database Hypoxic-Ischemic Encephalopathy Focus group
AU - Natarajan, Girija
AU - Hamrick, Shannon E.
AU - Zaniletti, Isabella
AU - Lee, Kyong Soon
AU - Mietzsch, Ulrike
AU - DiGeronimo, Robert
AU - Dizon, Maria L.V.
AU - Peeples, Eric S.
AU - Yanowitz, Toby D.
AU - Wu, Tai Wei
AU - Flibotte, John
AU - Joe, Priscilla
AU - Massaro, An N.
AU - Rao, Rakesh
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/8
Y1 - 2022/8
N2 - Objective: To assess the association between opioid exposure during therapeutic hypothermia (TH) for perinatal hypoxic-ischemic encephalopathy (HIE) and in-hospital outcomes. Study design: In this retrospective cohort study, linked data were accessed on infants ≥36 weeks gestation, who underwent TH for HIE, born from 2010–2016 in 23 Neonatal Intensive Care Units participating in Children’s Hospitals Neonatal Consortium and Pediatric Health Information Systems. We excluded infants who received opioids for >5 days. Results: The cohort (n = 1484) was categorized as No opioid [240(16.2%)], Low opioid (1–2 days) [574 (38.7%)] and High opioid group (HOG, 3–5 days) [670 (45.2%)]. After adjusting for HIE severity, opioids were not associated with abnormal MRI, but were associated with decreased likelihood of complete oral feeds at discharge. HOG had increased likelihood of prolonged hospital stay and ventilation. Conclusion: Opioid exposure during TH was not associated with abnormal MRI; its association with adverse short-term outcomes suggests need for cautious empiric use.
AB - Objective: To assess the association between opioid exposure during therapeutic hypothermia (TH) for perinatal hypoxic-ischemic encephalopathy (HIE) and in-hospital outcomes. Study design: In this retrospective cohort study, linked data were accessed on infants ≥36 weeks gestation, who underwent TH for HIE, born from 2010–2016 in 23 Neonatal Intensive Care Units participating in Children’s Hospitals Neonatal Consortium and Pediatric Health Information Systems. We excluded infants who received opioids for >5 days. Results: The cohort (n = 1484) was categorized as No opioid [240(16.2%)], Low opioid (1–2 days) [574 (38.7%)] and High opioid group (HOG, 3–5 days) [670 (45.2%)]. After adjusting for HIE severity, opioids were not associated with abnormal MRI, but were associated with decreased likelihood of complete oral feeds at discharge. HOG had increased likelihood of prolonged hospital stay and ventilation. Conclusion: Opioid exposure during TH was not associated with abnormal MRI; its association with adverse short-term outcomes suggests need for cautious empiric use.
UR - http://www.scopus.com/inward/record.url?scp=85135340981&partnerID=8YFLogxK
U2 - 10.1038/s41372-022-01400-x
DO - 10.1038/s41372-022-01400-x
M3 - Article
C2 - 35474129
AN - SCOPUS:85135340981
SN - 0743-8346
VL - 42
SP - 1017
EP - 1025
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 8
ER -