Opioid analgesia in necrotizing pancreatitis: Incidence and timing of a hidden crisis

S. P. McGuire; M. P. Anderson; T. K. Maatman; A. M. Roch; J. R. Butler; E. P. Ceppa; M. G. House; A. Nakeeb; T. K. Nguyen; C. M. Schmidt; N. J. Zyromski

doi:10.1016/j.amjsurg.2022.11.039

Opioid analgesia in necrotizing pancreatitis: Incidence and timing of a hidden crisis

S. P. McGuire, M. P. Anderson, T. K. Maatman, A. M. Roch, J. R. Butler, E. P. Ceppa, M. G. House, A. Nakeeb, T. K. Nguyen, C. M. Schmidt, N. J. Zyromski

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Abstract

Background: Rates of opioid usage during necrotizing pancreatitis (NP) disease course are unknown. We hypothesized that a significant number of NP patients were prescribed opioid analgesics chronically. Methods: Single institution IRB-approved retrospective study of 230 NP patients treated between 2015 and 2019. Results: Data were available for 198/230 (86%) patients. 166/198 (84%) were discharged from their index hospitalization with a prescription for an opioid. At the first clinic visit following hospitalization, 110/182 (60%) were using opioids. Six months after disease onset, 72/163 (44%) continued to require opioids. At disease resolution, 38/144 (26%) patients remained on opioid medications. The rate of active opioid prescriptions at six months after disease onset declined throughout the period studied from 68% in 2015 to 39% in 2019. Conclusions: Opioid prescriptions are common in NP. Despite decline over time, 1 in 4 patients remain on opioids at disease resolution. These data identify an opportunity to adjust analgesic prescription practice in NP patients.

Original language	English
Pages (from-to)	927-930
Number of pages	4
Journal	American journal of surgery
Volume	225
Issue number	5
DOIs	https://doi.org/10.1016/j.amjsurg.2022.11.039
State	Published - May 2023

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title = "Opioid analgesia in necrotizing pancreatitis: Incidence and timing of a hidden crisis",

abstract = "Background: Rates of opioid usage during necrotizing pancreatitis (NP) disease course are unknown. We hypothesized that a significant number of NP patients were prescribed opioid analgesics chronically. Methods: Single institution IRB-approved retrospective study of 230 NP patients treated between 2015 and 2019. Results: Data were available for 198/230 (86%) patients. 166/198 (84%) were discharged from their index hospitalization with a prescription for an opioid. At the first clinic visit following hospitalization, 110/182 (60%) were using opioids. Six months after disease onset, 72/163 (44%) continued to require opioids. At disease resolution, 38/144 (26%) patients remained on opioid medications. The rate of active opioid prescriptions at six months after disease onset declined throughout the period studied from 68% in 2015 to 39% in 2019. Conclusions: Opioid prescriptions are common in NP. Despite decline over time, 1 in 4 patients remain on opioids at disease resolution. These data identify an opportunity to adjust analgesic prescription practice in NP patients.",

author = "McGuire, {S. P.} and Anderson, {M. P.} and Maatman, {T. K.} and Roch, {A. M.} and Butler, {J. R.} and Ceppa, {E. P.} and House, {M. G.} and A. Nakeeb and Nguyen, {T. K.} and Schmidt, {C. M.} and Zyromski, {N. J.}",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2023",

month = may,

doi = "10.1016/j.amjsurg.2022.11.039",

language = "English",

volume = "225",

pages = "927--930",

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T1 - Opioid analgesia in necrotizing pancreatitis

T2 - Incidence and timing of a hidden crisis

AU - McGuire, S. P.

AU - Anderson, M. P.

AU - Maatman, T. K.

AU - Roch, A. M.

AU - Butler, J. R.

AU - Ceppa, E. P.

AU - House, M. G.

AU - Nakeeb, A.

AU - Nguyen, T. K.

AU - Schmidt, C. M.

AU - Zyromski, N. J.

PY - 2023/5

Y1 - 2023/5

N2 - Background: Rates of opioid usage during necrotizing pancreatitis (NP) disease course are unknown. We hypothesized that a significant number of NP patients were prescribed opioid analgesics chronically. Methods: Single institution IRB-approved retrospective study of 230 NP patients treated between 2015 and 2019. Results: Data were available for 198/230 (86%) patients. 166/198 (84%) were discharged from their index hospitalization with a prescription for an opioid. At the first clinic visit following hospitalization, 110/182 (60%) were using opioids. Six months after disease onset, 72/163 (44%) continued to require opioids. At disease resolution, 38/144 (26%) patients remained on opioid medications. The rate of active opioid prescriptions at six months after disease onset declined throughout the period studied from 68% in 2015 to 39% in 2019. Conclusions: Opioid prescriptions are common in NP. Despite decline over time, 1 in 4 patients remain on opioids at disease resolution. These data identify an opportunity to adjust analgesic prescription practice in NP patients.

AB - Background: Rates of opioid usage during necrotizing pancreatitis (NP) disease course are unknown. We hypothesized that a significant number of NP patients were prescribed opioid analgesics chronically. Methods: Single institution IRB-approved retrospective study of 230 NP patients treated between 2015 and 2019. Results: Data were available for 198/230 (86%) patients. 166/198 (84%) were discharged from their index hospitalization with a prescription for an opioid. At the first clinic visit following hospitalization, 110/182 (60%) were using opioids. Six months after disease onset, 72/163 (44%) continued to require opioids. At disease resolution, 38/144 (26%) patients remained on opioid medications. The rate of active opioid prescriptions at six months after disease onset declined throughout the period studied from 68% in 2015 to 39% in 2019. Conclusions: Opioid prescriptions are common in NP. Despite decline over time, 1 in 4 patients remain on opioids at disease resolution. These data identify an opportunity to adjust analgesic prescription practice in NP patients.

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AN - SCOPUS:85148726228

SN - 0002-9610

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SP - 927

EP - 930

JO - American journal of surgery

JF - American journal of surgery

IS - 5

ER -

Opioid analgesia in necrotizing pancreatitis: Incidence and timing of a hidden crisis

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