TY - JOUR
T1 - Open Ankle Fractures
T2 - What Predicts Infection? A Multicenter Study
AU - Cooke, Margaret E.
AU - Tornetta, Paul
AU - Firoozabadi, Reza
AU - Vallier, Heather
AU - Weinberg, Douglas S.
AU - Alton, Timothy B.
AU - Dillman, Megan R.
AU - Westberg, Jerald R.
AU - Schmidt, Andrew
AU - Bosse, Michael
AU - Leas, Daniel P.
AU - Archdeacon, Michael
AU - Kakazu, Rafael
AU - Nzegwu, Ifeanyi
AU - OToole, Robert V.
AU - Costales, Timothy G.
AU - Coale, Max
AU - Mullis, Brian
AU - Usmani, Rashad H.
AU - Egol, Kenneth
AU - Kottmeier, Stephen
AU - Sanders, David
AU - Jones, Cliff
AU - Miller, Anna N.
AU - Horwitz, Daniel S.
AU - Kempegowda, Harish
AU - Morshed, Saam
AU - Belaye, Tigist
AU - Teague, David
N1 - Publisher Copyright:
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Objective: To identify the patient, injury, and treatment factors associated with an acute infection during the treatment of open ankle fractures in a large multicenter retrospective review. To evaluate the effect of infectious complications on the rates of nonunion, malunion, and loss of reduction. Design: Multicenter retrospective review. Setting: Sixteen trauma centers. Patients: One thousand and 3 consecutive skeletally mature patients (514 men and 489 women) with open ankle fractures. Main Outcome Measures: Fracture-related infection (FRI) in open ankle fractures. Results: The charts of 1003 consecutive patients were reviewed, and 712 patients (357 women and 355 men) had at least 12 weeks of clinical follow-up. Their average age was 50 years (range 16–96), and average BMI was 31; they sustained OTA/AO types 44A (12%), 44B (58%), and 44C (30%) open ankle fractures. The rate FRI rate was 15%. A multivariable regression analysis identified male sex, diabetes, smoking, immunosuppressant use, time to wound closure, and wound location as independent risk factors for infection. There were 77 cases of malunion, nonunion, loss of reduction, and/or implant failure; FRI was associated with higher rates of these complications (P = 0.01). Conclusions: Several patient, injury, and surgical factors were associated with FRI in the treatment of open ankle fractures.
AB - Objective: To identify the patient, injury, and treatment factors associated with an acute infection during the treatment of open ankle fractures in a large multicenter retrospective review. To evaluate the effect of infectious complications on the rates of nonunion, malunion, and loss of reduction. Design: Multicenter retrospective review. Setting: Sixteen trauma centers. Patients: One thousand and 3 consecutive skeletally mature patients (514 men and 489 women) with open ankle fractures. Main Outcome Measures: Fracture-related infection (FRI) in open ankle fractures. Results: The charts of 1003 consecutive patients were reviewed, and 712 patients (357 women and 355 men) had at least 12 weeks of clinical follow-up. Their average age was 50 years (range 16–96), and average BMI was 31; they sustained OTA/AO types 44A (12%), 44B (58%), and 44C (30%) open ankle fractures. The rate FRI rate was 15%. A multivariable regression analysis identified male sex, diabetes, smoking, immunosuppressant use, time to wound closure, and wound location as independent risk factors for infection. There were 77 cases of malunion, nonunion, loss of reduction, and/or implant failure; FRI was associated with higher rates of these complications (P = 0.01). Conclusions: Several patient, injury, and surgical factors were associated with FRI in the treatment of open ankle fractures.
KW - Ankle
KW - Fracture
KW - Infection
KW - Open ankle
KW - Open fracture
UR - http://www.scopus.com/inward/record.url?scp=85122284347&partnerID=8YFLogxK
U2 - 10.1097/BOT.0000000000002293
DO - 10.1097/BOT.0000000000002293
M3 - Article
C2 - 34711768
AN - SCOPUS:85122284347
SN - 0890-5339
VL - 36
SP - 43
EP - 48
JO - Journal of orthopaedic trauma
JF - Journal of orthopaedic trauma
IS - 1
ER -