TY - JOUR
T1 - Ontogeny of Salivary Epidermal Growth Factor and Necrotizing Enterocolitis
AU - Warner, Barbara B.
AU - Ryan, Ann Ladd
AU - Seeger, Kimberly
AU - Leonard, Anthony C.
AU - Erwin, Christopher R.
AU - Warner, Brad W.
N1 - Funding Information:
Supported by a grant from the National Institute of Diabetes and Digestive and Kidney Diseases (RO3 DK61596-02).
PY - 2007/4
Y1 - 2007/4
N2 - Objective: To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC). Study design: Salivary EGF was prospectively measured in 327 infants with gestational ages from 23 weeks to term. Infants of ≤32 weeks' gestation (n = 261) were followed with weekly sEGF measurements through 3 weeks of life. Multivariable regression analyses were used to determine variables significantly related to sEGF levels and to identify predictors of NEC. Results: Over the first 3 weeks of life, sEGF increased across gestational age and postnatal age categories. In multivariable models, gestational age was a significant predictor of sEGF levels (P < .009). In a cohort of 27 infants who had NEC, gestational age, race, and changes in sEGF levels between weeks of life 1 and 2 were predictive of the development of NEC. These infants had lower sEGF at week 1 and greater increases from week 1 to week 2 compared with infants without NEC. Conclusions: There is a positive relation between sEGF levels and gestational age. Patterns of sEGF levels over the first 2 weeks of life were significantly related to development of NEC in very low birth weight infants.
AB - Objective: To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC). Study design: Salivary EGF was prospectively measured in 327 infants with gestational ages from 23 weeks to term. Infants of ≤32 weeks' gestation (n = 261) were followed with weekly sEGF measurements through 3 weeks of life. Multivariable regression analyses were used to determine variables significantly related to sEGF levels and to identify predictors of NEC. Results: Over the first 3 weeks of life, sEGF increased across gestational age and postnatal age categories. In multivariable models, gestational age was a significant predictor of sEGF levels (P < .009). In a cohort of 27 infants who had NEC, gestational age, race, and changes in sEGF levels between weeks of life 1 and 2 were predictive of the development of NEC. These infants had lower sEGF at week 1 and greater increases from week 1 to week 2 compared with infants without NEC. Conclusions: There is a positive relation between sEGF levels and gestational age. Patterns of sEGF levels over the first 2 weeks of life were significantly related to development of NEC in very low birth weight infants.
UR - http://www.scopus.com/inward/record.url?scp=33947211314&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2006.11.059
DO - 10.1016/j.jpeds.2006.11.059
M3 - Article
C2 - 17382110
AN - SCOPUS:33947211314
SN - 0022-3476
VL - 150
SP - 358
EP - 363
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 4
ER -