Abstract
Single doses of diazepam induced peak impairment of performance on cognitive and psychomotor tasks early (20 min after ingestion), when blood levels had reached less than two thirds of their eventual plateau. Alcohol did not have this effect. Early peak impairment and the acute tolerance that follows it contribute greatly to the lack of correlation between diazepam plasma level and performance impairment.
Original language | English |
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Pages (from-to) | 534-538 |
Number of pages | 5 |
Journal | Clinical pharmacology and therapeutics |
Volume | 30 |
Issue number | 4 |
DOIs | |
State | Published - Oct 1981 |