Oncologic outcomes of extended neck dissections in human papillomavirus-related oropharyngeal squamous cell carcinoma

Joseph Zenga, Patrik Pipkorn, Evan M. Graboyes, Eliot J. Martin, Jason T. Rich, Eric J. Moore, Bruce H. Haughey, Ryan S. Jackson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Oncologic outcomes of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) requiring resection of major muscular or neurovascular tissue during neck dissection for invasive nodal disease remain uncertain. Methods: Patients with HPV-related oropharyngeal SCC requiring resection of major muscular or neurovascular tissue during their neck dissections were retrospectively identified. Results: Seventy-two patients were included. Regional and distant recurrences occurred in 6% and 17% of patients. Advanced T classification, pathological node number of 5 or more, and omission of adjuvant therapy were associated with decreased disease-free survival (DFS). The addition of adjuvant chemotherapy was not associated with improved survival. Conclusion: Patients with invasive nodal disease from HPV-related oropharyngeal SCC can be managed with up-front surgery and adjuvant therapy, as indicated with good regional control. Although distant recurrence was the primary site of failure, adjuvant chemotherapy was not associated with improved outcomes. The T classification, node number, and adjuvant radiotherapy are independent prognostic factors in this patient population.

Original languageEnglish
Pages (from-to)955-962
Number of pages8
JournalHead and Neck
Volume40
Issue number5
DOIs
StatePublished - May 2018

Keywords

  • extralymphatic
  • human papillomavirus
  • neck dissection
  • oncologic outcomes
  • oropharynx

Fingerprint

Dive into the research topics of 'Oncologic outcomes of extended neck dissections in human papillomavirus-related oropharyngeal squamous cell carcinoma'. Together they form a unique fingerprint.

Cite this