TY - JOUR
T1 - On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes
AU - Collier, Ivan E.
AU - Bruns, Gail A.P.
AU - Goldberg, Gregory I.
AU - Gerhard, Daniela S.
N1 - Funding Information:
We thank Dr. D. Paterson for his gift of the DNA from the chromosome 3-only hybrid cell line and Ginger Roberts for preparation of this manuscript. This study was supported by Grants AR 39427 and AR 12129 and by the Monsanto Company/Washington University Research Agreement to Ivan E. Collier and Gregory Goldberg and by NIH Grant NS26854 to Daniela S. Gerhard.
PY - 1991/3
Y1 - 1991/3
N2 - The 72- and 92-kDa type IV collagenases are members of a group of secreted zinc metalloproteases. Two members of this family, collagenase and stromelysin, have previously been localized to the long arm of chromosome 11. Here we assign both of the two type IV collagenase genes to human chromosome 16. By sequencing, the 72-kDa gene is shown to consist of 13 exons, 3 more than have been reported for the other members of this gene family. The extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72- and 92-kDa type IV collagenases. The evolutionary relationship among the members of this gene family is discussed.
AB - The 72- and 92-kDa type IV collagenases are members of a group of secreted zinc metalloproteases. Two members of this family, collagenase and stromelysin, have previously been localized to the long arm of chromosome 11. Here we assign both of the two type IV collagenase genes to human chromosome 16. By sequencing, the 72-kDa gene is shown to consist of 13 exons, 3 more than have been reported for the other members of this gene family. The extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72- and 92-kDa type IV collagenases. The evolutionary relationship among the members of this gene family is discussed.
UR - https://www.scopus.com/pages/publications/0026096865
U2 - 10.1016/0888-7543(91)90408-7
DO - 10.1016/0888-7543(91)90408-7
M3 - Article
C2 - 1851724
AN - SCOPUS:0026096865
SN - 0888-7543
VL - 9
SP - 429
EP - 434
JO - Genomics
JF - Genomics
IS - 3
ER -