@article{b034c1a60faf47e2afa6769f355cc623,
title = "On the role of the corpus callosum in interhemispheric functional connectivity in humans",
abstract = "Resting state functional connectivity is defined in terms of temporal correlations between physiologic signals, most commonly studied using functional magnetic resonance imaging. Major features of functional connectivity correspond to structural (axonal) connectivity. However, this relation is not one-to-one. Interhemispheric functional connectivity in relation to the corpus callosum presents a case in point. Specifically, several reports have documented nearly intact interhemispheric functional connectivity in individuals in whom the corpus callosum (the major commissure between the hemispheres) never develops. To investigate this question, we assessed functional connectivity before and after surgical section of the corpus callosum in 22 patients with medically refractory epilepsy. Section of the corpus callosum markedly reduced interhemispheric functional connectivity. This effect was more profound in multimodal associative areas in the frontal and parietal lobe than primary regions of sensorimotor and visual function. Moreover, no evidence of recovery was observed in a limited sample in which multiyear, longitudinal follow-up was obtained. Comparison of partial vs. complete callosotomy revealed several effects implying the existence of polysynaptic functional connectivity between remote brain regions. Thus, our results demonstrate that callosal as well as extracallosal anatomical connections play a role in the maintenance of interhemispheric functional connectivity.",
keywords = "Callosotomy, Corpus callosum, Functional connectivity, Resting state, Structural connectivity",
author = "Roland, {Jarod L.} and Snyder, {Abraham Z.} and Hacker, {Carl D.} and Anish Mitra and Shimony, {Joshua S.} and Limbrick, {David D.} and Raichle, {Marcus E.} and Smyth, {Matthew D.} and Leuthardt, {Eric C.}",
note = "Funding Information: ACKNOWLEDGMENTS. We thank Nicholas Szrama, Mrinal Pawa, Ravi Chacko, Joseph Humphries, Donna Dierker, Nicholas Metcalf, and Mario Ortega for useful contributions, discussions, and guidance during data analysis and manuscript preparation, and we thank the patients and their families for contributing to this research. This study was supported by NIH Grant R25 NS090978, the Knight-Davidson family, The McDonnell Center for Systems Neuroscience, Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University in St. Louis, and Neuroimaging Informatics and Analysis Center Grant 1P30NS098577. Funding Information: We thank Nicholas Szrama, Mrinal Pawa, Ravi Chacko, Joseph Humphries, Donna Dierker, Nicholas Metcalf, and Mario Ortega for useful contributions, discussions, and guidance during data analysis and manuscript preparation, and we thank the patients and their families for contributing to this research. This study was supported by NIH Grant R25 NS090978, the Knight-Davidson family, The McDonnell Center for Systems Neuroscience, Eunice Kennedy Shriver National Institute of Child Health & Human Development of the National Institutes of Health under Award U54 HD087011 to the Intellectual and Developmental Disabilities Research Center at Washington University in St. Louis, and Neuroimaging Informatics and Analysis Center Grant 1P30NS098577.",
year = "2017",
month = dec,
day = "12",
doi = "10.1073/pnas.1707050114",
language = "English",
volume = "114",
pages = "13278--13283",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "50",
}